RED TERAV - Investigadores

Investigadores

GENYO. ibs.Granada. Universidad de Granada

Investigadores
Publicaciones

Francisco Martin Molina

Investigador principal

Grupo de Investigación: GENYO. ibs.Granada. Universidad de Granada

Pablo Galindo Moreno

Investigador colaborador

Grupo de Investigación: GENYO. ibs.Granada. Universidad de Granada

PAULA FERNANDEZ COCA FERNANDEZ COCA

Investigador colaborador

Grupo de Investigación: GENYO. ibs.Granada. Universidad de Granada

Rosario María Sánchez Martín

Investigador colaborador

Grupo de Investigación: GENYO. ibs.Granada. Universidad de Granada

Sergio Granados Principal

Investigador colaborador

Grupo de Investigación: GENYO. ibs.Granada. Universidad de Granada

VERONICA AYLLON CASES

Investigador colaborador

Grupo de Investigación: GENYO. ibs.Granada. Universidad de Granada

Aguilar-González A., Martos-Jamai I., Ramos-Hernández I., Molina-Estévez F.J., Villao N.V., Puig-Serra P., Rodríguez-Perales S., Torres R., Labun K., Sánchez-Martín R.M., Díaz-Mochón J.J., Martín F.. A novel Dual-guide CRISPR–Cas13 strategy improves specificity for single-nucleotide variant detection. Nucleic Acids Research. 24 March 2026. DOI: 10.1093/nar/gkag161.

Impacto: 13.1. Cuartil: Q1 (1er decil)

Pozo-Agundo A., García-Rodríguez S., Antúnez-Rodríguez A., Chica-Redecillas L., Cejas R.B., Lyra-Leite D., Porras-Quesada P., Gómez-Sánchez J., Mirón-Pozo B., Álvarez-Cubero M.J., Burridge P.W., Martin F., Martínez-González L.J., Dávila-Fajardo C.L.. Functional in vitro assessment of the HER2 Ile655Val variant on trastuzumab-induced cardiotoxicity in human cardiomyocytes. European Journal of Pharmacology. 20 January 2026. DOI: 10.1016/j.ejphar.2025.178484.

Impacto: 4.7. Cuartil: Q1

Schambach A., Martin F., Maccalli C.. Editorial: Community Series in Engineered Immune Cells in Cancer Immunotherapy (EICCI), volume II. Frontiers in Immunology. 2026. DOI: 10.3389/fimmu.2026.1833581.

Impacto: 5.9. Cuartil: Q1

López-Rodríguez A., Martinez-Ruiz L., Morales-Gallel R., Florido J., Bermejo-Casares F., Garcia-Verdugo J.M., Estebané M.M., Carriel V., Maldonado-Pérez N., González-García P., Ahmadpour S.T., Ramírez-Casas Y., Martín F., Dumas J.F., Vandier C., Yang Y., Acuña-Castroviejo D., Escames G.. Melatonin Overcomes Cancer Multidrug Resistance by Downregulating ABCB1 Expression and Modulating Mitochondrial Function. Journal of Pineal Research. November 2025. DOI: 10.1111/jpi.70096.

Impacto: 6.3. Cuartil: Q1 (1er decil)

Puig-Serra P., Hinckley-Boned A., Tristán-Manzano M., Rio P., Torres-Ruiz R., Rodriguez-Perales S., Martín F.. Risk and Benefit Assessment of Gene Therapy with Lentiviral Vectors and Hematopoietic Stem Cells: The Skysona Case. Human Gene Therapy. 26 September 2025. DOI: 10.1177/10430342251372474.

Impacto: 4.0. Cuartil: Q1

Delgadillo J., Martin F., Carmona G., Canals J.M., Rio P., Eguizabal C., Prosper F., Avendaño-Solá C.. Regulatory Strategies for Accelerating the Translation of Gene Therapies to Clinical Practice: Focus on GMO Considerations. Human Gene Therapy. 26 September 2025. DOI: 10.1177/10430342251372063.

Impacto: 4.0. Cuartil: Q1

Ramos-Hernández I., Fuster-García C., Aguilar-González A., Lozano-Vinagre M.L., Guenechea-Amurrio G., Sanchez-Luque F.J., Gonçalves M.A.F.V., Cathomen T., Muñoz P., Molina-Estévez F.J., Martín F.. Donor insertion into CX3CR1 allows epigenetic modulation of a constitutive promoter on hematopoietic stem cells and its activation upon myeloid differentiation. Nucleic Acids Research. 8 May 2025. DOI: 10.1093/nar/gkaf344.

Impacto: 13.1. Cuartil: Q1 (1er decil)

Hinckley-Boned A., Barbero-Jiménez C., Tristán-Manzano M., Maldonado-Perez N., Hudecek M., Justicia-Lirio P., Martin F.. Tailoring CAR surface density and dynamics to improve CAR-T cell therapy. Journal for Immunotherapy of Cancer. 29 April 2025. DOI: 10.1136/jitc-2024-010702.

Impacto: 10.6. Cuartil: Q1 (1er decil)

Lara P., Aguilar-González A., Martín F., Mesas C., Moreno J., Rama A.R.. Exploring miR-21 Knock-Out Using CRISPR/Cas as a Treatment for Lung Cancer. Genes. February 2025. DOI: 10.3390/genes16020133.

Impacto: 2.8. Cuartil: Q2

Justicia-Lirio P., Tristán-Manzano M., Maldonado-Pérez N., Barbero-Jiménez C., Cortijo-Gutiérrez M., Pavlovic K., Molina-Estevez F.J., Muñoz P., Hinckley-Boned A., Rodriguez-Madoz J.R., Prosper F., Griñán-Lison C., Navarro-Marchal S.A., Panisello C., Muñoz-Ballester J., González-Sierra P.A., Herrera C., Marchal J.A., Martín F.. First-in-class transactivator-free, doxycycline-inducible IL-18-engineered CAR-T cells for relapsed/refractory B cell lymphomas. Molecular Therapy Nucleic Acids. 10 December 2024. DOI: 10.1016/j.omtn.2024.102308.

Impacto: 6.5. Cuartil: Q1

Carrillo-Gálvez A.B., Zurita F., Guerra-Valverde J.A., Aguilar-González A., Abril-García D., Padial-Molina M., Olaechea A., Martín-Morales N., Martín F., Valle F.O., Moreno P.G.. NLRP3 and AIM2 inflammasomes expression is modified by LPS and titanium ions increasing the release of active IL-1β in alveolar bone-derived MSCs. Stem Cells Translational Medicine. August 2024. DOI: 10.1093/stcltm/szae042.

Impacto: 5.4. Cuartil: Q1

Rangel-Peláez C., Martínez-Gutiérrez L., Tristán-Manzano M., Callejas J.L., Ortego-Centeno N., Martín F., Martín J.. CD19 CAR-T cell therapy: a new dawn for autoimmune rheumatic diseases?. Frontiers in Immunology. 2024. DOI: 10.3389/fimmu.2024.1502712.

Impacto: 5.7. Cuartil: Q1

Pavlovic K., Carmona-Luque M., Corsi G.I., Maldonado-Pérez N., Molina-Estevez F.J., Peralbo-Santaella E., Cortijo-Gutiérrez M., Justicia-Lirio P., Tristán-Manzano M., Ronco-Díaz V., Ballesteros-Ribelles A., Millán-López A., Heredia-Velázquez P., Fuster-García C., Cathomen T., Seemann S.E., Gorodkin J., Martin F., Herrera C., Benabdellah K.. Generating universal anti-CD19 CAR T cells with a defined memory phenotype by CRISPR/Cas9 editing and safety evaluation of the transcriptome. Frontiers in Immunology. 2024. DOI: 10.3389/fimmu.2024.1401683.

Impacto: 5.7. Cuartil: Q1

Cavazza A., Hendel A., Bak R.O., Rio P., Güell M., Lainšček D., Arechavala-Gomeza V., Peng L., Hapil F.Z., Harvey J., Ortega F.G., Gonzalez-Martinez C., Lederer C.W., Mikkelsen K., Gasiunas G., Kalter N., Gonçalves M.A.F.V., Petersen J., Garanto A., Montoliu L., Maresca M., Seemann S.E., Gorodkin J., Mazini L., Sanchez R., Rodriguez-Madoz J.R., Maldonado-Pérez N., Laura T., Schmueck-Henneresse M., Maccalli C., Grünewald J., Carmona G., Kachamakova-Trojanowska N., Miccio A., Martin F., Turchiano G., Cathomen T., Luo Y., Tsai S.Q., Benabdellah K.. Progress and harmonization of gene editing to treat human diseases: Proceeding of COST Action CA21113 GenE-HumDi. Molecular Therapy Nucleic Acids. 12 December 2023. DOI: 10.1016/j.omtn.2023.102066.

Impacto: 6.5. Cuartil: Q1

Jaccard A., Wyss T., Maldonado-Pérez N., Rath J.A., Bevilacqua A., Peng J.J., Lepez A., Von Gunten C., Franco F., Kao K.C., Camviel N., Martín F., Ghesquière B., Migliorini D., Arber C., Romero P., Ho P.C., Wenes M.. Reductive carboxylation epigenetically instructs T cell differentiation. Nature. 28 September 2023. DOI: 10.1038/s41586-023-06546-y.

Impacto: 50.5. Cuartil: Q1 (1er decil)

Martinez-Navajas G., Ceron-Hernandez J., Simon I., Lupiañez P., Diaz-McLynn S., Perales S., Modlich U., Guerrero J.A., Martin F., Sevivas T., Lozano M.L., Rivera J., Ramos-Mejia V., Tersteeg C., Real P.J.. Lentiviral gene therapy reverts GPIX expression and phenotype in Bernard-Soulier syndrome type C. Molecular Therapy Nucleic Acids. 12 September 2023. DOI: 10.1016/j.omtn.2023.06.008.

Impacto: 6.5. Cuartil: Q1

Quintero-Espinosa D.A., Sanchez-Hernandez S., Velez-Pardo C., Martin F., Jimenez-Del-Rio M.. LRRK2 Knockout Confers Resistance in HEK-293 Cells to Rotenone-Induced Oxidative Stress, Mitochondrial Damage, and Apoptosis. International Journal of Molecular Sciences. July 2023. DOI: 10.3390/ijms241310474.

Impacto: 4.9. Cuartil: Q1

Tristán-Manzano M., Maldonado-Pérez N., Justicia-Lirio P., Cortijo-Gutierréz M., Tristán-Ramos P., Blanco-Benítez C., Pavlovic K., Aguilar-González A., Muñoz P., Molina-Estevez F.J., Griesche V., Marchal J.A., Heras S.R., Benabdellah K., Martin F.. Lentiviral vectors for inducible, transactivator-free advanced therapy medicinal products: Application to CAR-T cells. Molecular Therapy Nucleic Acids. 13 June 2023. DOI: 10.1016/j.omtn.2023.03.018.

Impacto: 6.5. Cuartil: Q1

Sánchez-Guijo F., Avendaño-Solá C., Badimón L., Bueren J.A., Canals J.M., Delgadillo J., Delgado J., Eguizábal C., Fernández-Santos M.E., García-Olmo D., González-Aseguinolaza G., Juan M., Martín F., Mata R., Montserrat N., Pérez-Martínez A., Pérez-Simón J.A., Prósper F., Urbano-Ispizua Á., Zapata A.G., Sureda A., Moraleda J.M.. Role of Hospital Exemption in Europe: position paper from the Spanish Advanced Therapy Network (TERAV). Bone Marrow Transplantation. June 2023. DOI: 10.1038/s41409-023-01962-0.

Impacto: 4.5. Cuartil: Q1

Martin F., Schambach A., Maccalli C.. Editorial: Engineered immune cells in cancer immunotherapy (EICCI). Frontiers in Immunology. 20 December 2022. DOI: 10.3389/fimmu.2022.1119363.

Impacto: 7.3. Cuartil: Q1

Maldonado-Pérez N., Tristán-Manzano M., Justicia-Lirio P., Martínez-Planes E., Muñoz P., Pavlovic K., Cortijo-Gutiérrez M., Blanco-Benítez C., Castella M., Juan M., Wenes M., Romero P., Molina-Estévez F.J., Marañón C., Herrera C., Benabdellah K., Martin F.. Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma. Frontiers in Immunology. 6 October 2022. DOI: 10.3389/fimmu.2022.1011858.

Impacto: 7.3. Cuartil: Q1

Tristán-Manzano M., Maldonado-Pérez N., Justicia-Lirio P., Muñoz P., Cortijo-Gutiérrez M., Pavlovic K., Jiménez-Moreno R., Nogueras S., Carmona M.D., Sánchez-Hernández S., Aguilar-González A., Castella M., Juan M., Marañón C., Marchal J.A., Benabdellah K., Herrera C., Martin F.. Erratum: Physiological lentiviral vectors for the generation of improved CAR-T cells (Molecular Therapy - Oncolytics (2022) 25 (335–349), (S2372770522000687), (10.1016/j.omto.2022.05.003)). Molecular Therapy Oncolytics. 15 September 2022. DOI: 10.1016/j.omto.2022.07.005.

Impacto: 5.7. Cuartil: Q2

Cueto-Ureña C., Mocholí E., Escrivá-Fernández J., González-Granero S., Sánchez-Hernández S., Solana-Orts A., Ballester-Lurbe B., Benabdellah K., Guasch R.M., García-Verdugo J.M., Martín F., Coffer P.J., Pérez-Roger I., Poch E.. Rnd3 Expression is Necessary to Maintain Mitochondrial Homeostasis but Dispensable for Autophagy. Frontiers in Cell and Developmental Biology. 27 June 2022. DOI: 10.3389/fcell.2022.834561.

Impacto: 5.5. Cuartil: Q1

Tristán-Manzano M., Maldonado-Pérez N., Justicia-Lirio P., Muñoz P., Cortijo-Gutiérrez M., Pavlovic K., Jiménez-Moreno R., Nogueras S., Carmona M.D., Sánchez-Hernández S., Aguilar-González A., Castella M., Juan M., Marañón C., Marchal J.A., Benabdellah K., Herrera C., Martin F.. Physiological lentiviral vectors for the generation of improved CAR-T cells. Molecular Therapy Oncolytics. 16 June 2022. DOI: 10.1016/j.omto.2022.05.003.

Impacto: 5.7. Cuartil: Q2

Aguilar-González A., González-Correa J.E., Barriocanal-Casado E., Ramos-Hernández I., Lerma-Juárez M.A., Greco S., Rodríguez-Sevilla J.J., Molina-Estévez F.J., Montalvo-Romeral V., Ronzitti G., Sánchez-Martín R.M., Martín F., Muñoz P.. Isogenic GAA-KO Murine Muscle Cell Lines Mimicking Severe Pompe Mutations as Preclinical Models for the Screening of Potential Gene Therapy Strategies. International Journal of Molecular Sciences. June-1 2022. DOI: 10.3390/ijms23116298.

Impacto: 5.6. Cuartil: Q1

Wenes M., Jaccard A., Wyss T., Maldonado-Pérez N., Teoh S.T., Lepez A., Renaud F., Franco F., Waridel P., Yacoub Maroun C., Tschumi B., Dumauthioz N., Zhang L., Donda A., Martín F., Migliorini D., Lunt S.Y., Ho P.C., Romero P.. The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function. Cell Metabolism. 3 May 2022. DOI: 10.1016/j.cmet.2022.03.013.

Impacto: 29.0. Cuartil: Q1 (1er decil)

Cortijo-Gutiérrez M., Sánchez-Hernández S., Tristán-Manzano M., Maldonado-Pérez N., Lopez-Onieva L., Real P.J., Herrera C., Marchal J.A., Martin F., Benabdellah K.. Improved functionality of integration-deficient lentiviral vectors (IDLVs) by the inclusion of IS<inf>2</inf> protein docks. Pharmaceutics. August 2021. DOI: 10.3390/pharmaceutics13081217.

Impacto: 6.525. Cuartil: Q1

Navarro-Marchal S.A., GrinÌ án-Lisan C., Entrena J.M., Ruiz-Alcalá G., Tristán-Manzano M., Martin F., Pérez-Victoria I., Peula-Garciá J.M., Marchal J.A.. Anti-CD44-Conjugated Olive Oil Liquid Nanocapsules for Targeting Pancreatic Cancer Stem Cells. Biomacromolecules. 12 April 2021. DOI: 10.1021/acs.biomac.0c01546.

Impacto: 6.978. Cuartil: Q1 (1er decil)

Guerrouahen B., Elnaggar M., Al-Mohannadi A., Kizhakayil D., Bonini C., Benjamin R., Brentjens R., Buchholz C.J., Casorati G., Ferrone S., Locke F.L., Martin F., Schambach A., Turtle C., Veys P., van der Vliet H.J., Maccalli C., Benabdellah K., Bos T., Cugno C., Johnston I., Mohamed A., Ponterio E., Abu Rasheed H.M., Roelands J., Taha R.Y.. Proceedings From the First International Workshop at Sidra Medicine: “Engineered Immune Cells in Cancer Immunotherapy (EICCI): From Discovery to Off-the-Shelf Development”, 15th–16th February 2019, Doha, Qatar. Frontiers in Immunology. 14 January 2021. DOI: 10.3389/fimmu.2020.589381.

Impacto: 8.786. Cuartil: Q1

Gutierrez-Guerrero A., Abrey Recalde M.J., Mangeot P.E., Costa C., Bernadin O., Périan S., Fusil F., Froment G., Martinez-Turtos A., Krug A., Martin F., Benabdellah K., Ricci E.P., Giovannozzi S., Gijsbers R., Ayuso E., Cosset F.L., Verhoeyen E.. Baboon Envelope Pseudotyped “Nanoblades” Carrying Cas9/gRNA Complexes Allow Efficient Genome Editing in Human T, B, and CD34+ Cells and Knock-in of AAV6-Encoded Donor DNA in CD34+ Cells. Frontiers in Genome Editing. 2021. DOI: 10.3389/fgeed.2021.604371.

Simion V., Loussouarn C., Laurent Y., Roncali L., Gosset D., Reverchon F., Rousseau A., Martin F., Midoux P., Pichon C., Garcion E., Baril P.. LentiRILES, a miRNA-ON sensor system for monitoring the functionality of miRNA in cancer biology and therapy. RNA Biology. 2021. DOI: 10.1080/15476286.2021.1978202.

Impacto: 4.766. Cuartil: Q2

Aheget H., Mazini L., Martin F., Belqat B., Marchal J.A., Benabdellah K.. Exosomes: Their role in pathogenesis, diagnosis and treatment of diseases. Cancers. 1 January 2021. DOI: 10.3390/cancers13010084.

Impacto: 6.575. Cuartil: Q1

Muñoz P., Tristán-Manzano M., Sánchez-Gilabert A., Santilli G., Galy A., Thrasher A.J., Martin F.. WAS Promoter-Driven Lentiviral Vectors Mimic Closely the Lopsided WASP Expression during Megakaryocytic Differentiation. Molecular Therapy Methods and Clinical Development. 11 December 2020. DOI: 10.1016/j.omtm.2020.09.006.

Impacto: 6.698. Cuartil: Q1

Simion V., Henriet E., Juric V., Aquino R., Loussouarn C., Laurent Y., Martin F., Midoux P., Garcion E., Pichon C., Baril P.. Intracellular trafficking and functional monitoring of miRNA delivery in glioblastoma using lipopolyplexes and the miRNA-ON RILES reporter system. Journal of Controlled Release. 10 November 2020. DOI: 10.1016/j.jconrel.2020.08.028.

Impacto: 9.776. Cuartil: Q1 (1er decil)

Carrillo-Gálvez A.B., Quintero J.E., Rodríguez R., Menéndez S.T., Victoria González M., Blanco-Lorenzo V., Allonca E., de Araújo Farias V., González-Correa J.E., Erill-Sagalés N., Martínez-Zubiaurre I., Hellevik T., Sánchez-Hernández S., Muñoz P., Zurita F., Martín F., Rodríguez-Manzaneque J.C., Anderson P.. GARP promotes the proliferation and therapeutic resistance of bone sarcoma cancer cells through the activation of TGF-β. Cell Death and Disease. November 2020. DOI: 10.1038/s41419-020-03197-z.

Impacto: 8.469. Cuartil: Q1

González-García P., Hidalgo-Gutiérrez A., Mascaraque C., Barriocanal-Casado E., Bakkali M., Ziosi M., Abdihankyzy U.B., Sánchez-Hernández S., Escames G., Prokisch H., Martín F., Quinzii C.M., López L.C.. Coenzyme Q10 modulates sulfide metabolism and links the mitochondrial respiratory chain to pathways associated to one carbon metabolism. Human Molecular Genetics. 1 October 2020. DOI: 10.1093/hmg/ddaa214.

Impacto: 6.15. Cuartil: Q1

Baliñas-Gavira C., Rodríguez M.I., Andrades A., Cuadros M., Álvarez-Pérez J.C., Álvarez-Prado Á.F., de Yébenes V.G., Sánchez-Hernández S., Fernández-Vigo E., Muñoz J., Martín F., Ramiro A.R., Martínez-Climent J.A., Medina P.P.. Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL. Leukemia. 1 October 2020. DOI: 10.1038/s41375-020-0919-5.

Impacto: 11.528. Cuartil: Q1 (1er decil)

Pavlovic K., Tristán-Manzano M., Maldonado-Pérez N., Cortijo-Gutierrez M., Sánchez-Hernández S., Justicia-Lirio P., Carmona M.D., Herrera C., Martin F., Benabdellah K.. Using Gene Editing Approaches to Fine-Tune the Immune System. Frontiers in Immunology. 29 September 2020. DOI: 10.3389/fimmu.2020.570672.

Impacto: 7.561. Cuartil: Q1

Tristán-Manzano M., Justicia-Lirio P., Maldonado-Pérez N., Cortijo-Gutiérrez M., Benabdellah K., Martin F.. Externally-Controlled Systems for Immunotherapy: From Bench to Bedside. Frontiers in Immunology. 4 September 2020. DOI: 10.3389/fimmu.2020.02044.

Impacto: 7.561. Cuartil: Q1

Aheget H., Tristán-Manzano M., Mazini L., Cortijo-Gutierrez M., Galindo-Moreno P., Herrera C., Martin F., Marchal J.A., Benabdellah K.. Exosome: A new player in translational nanomedicine. Journal of Clinical Medicine. August 2020. DOI: 10.3390/jcm9082380.

Impacto: 4.241. Cuartil: Q1

Sánchez-Hernández S., Aguilar-González A., Guijarro-Albaladejo B., Maldonado-Pérez N., Ramos-Hernández I., Cortijo-Gutiérrez M., Martín R.M.S., Benabdellah K., Martin F.. Development of cellular models to study efficiency and safety of gene edition by homologous directed recombination using the crispr/cas9 system. Cells. June 2020. DOI: 10.3390/cells9061492.

Impacto: 6.6. Cuartil: Q2

Benabdellah K., Sánchez-Hernández S., Aguilar-González A., Maldonado-Pérez N., Gutierrez-Guerrero A., Cortijo-Gutierrez M., Ramos-Hernández I., Tristán-Manzano M., Galindo-Moreno P., Herrera C., Martin F.. Genome-edited adult stem cells: Next-generation advanced therapy medicinal products. Stem Cells Translational Medicine. 1 June 2020. DOI: 10.1002/sctm.19-0338.

Impacto: 6.94. Cuartil: Q1

Carrillo-Gálvez A.B., Gálvez-Peisl S., González-Correa J.E., de Haro-Carrillo M., Ayllón V., Carmona-Sáez P., Ramos-Mejía V., Galindo-Moreno P., Cara F.E., Granados-Principal S., Muñoz P., Martin F., Anderson P.. GARP is a key molecule for mesenchymal stromal cell responses to TGF-β and fundamental to control mitochondrial ROS levels. Stem Cells Translational Medicine. 1 May 2020. DOI: 10.1002/sctm.19-0372.

Impacto: 6.94. Cuartil: Q1

Muñoz-Fernández R., De La Mata C., Requena F., Martín F., Fernandez-Rubio P., Llorca T., Ruiz-Magaña M.J., Ruiz-Ruiz C., Olivares E.G.. Human predecidual stromal cells are mesenchymal stromal/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortion. Stem Cell Research and Therapy. 14 June 2019. DOI: 10.1186/s13287-019-1284-z.

Impacto: 5.116. Cuartil: Q1

Martín F., Tristán-Manzano M., Maldonado-Pérez N., Sánchez-Hernández S., Benabdellah K., Cobo M.. Stable genetic modification of mesenchymal stromal cells using lentiviral vectors. Methods in Molecular Biology. 2019. DOI: 10.1007/978-1-4939-9065-8_17.

Sánchez-Hernández S., Gutierrez-Guerrero A., Martín-Guerra R., Cortijo-Gutierrez M., Tristán-Manzano M., Rodriguez-Perales S., Sanchez L., Garcia-Perez J.L., Chato-Astrain J., Fernandez-Valades R., Carrillo-Galvez A.B., Anderson P., Montes R., Real P.J., Martin F., Benabdellah K.. The IS2 Element Improves Transcription Efficiency of Integration-Deficient Lentiviral Vector Episomes. Molecular Therapy Nucleic Acids. 7 December 2018. DOI: 10.1016/j.omtn.2018.08.007.

Impacto: 5.919. Cuartil: Q1

de Araújo Farias V., Carrillo-Gálvez A.B., Martín F., Anderson P.. TGF-β and mesenchymal stromal cells in regenerative medicine, autoimmunity and cancer. Cytokine and Growth Factor Reviews. October 2018. DOI: 10.1016/j.cytogfr.2018.06.002.

Impacto: 5.458. Cuartil: Q1

de Araujo Farias V., O'Valle F., Serrano-Saenz S., Anderson P., Andrés E., López-Peñalver J., Tovar I., Nieto A., Santos A., Martín F., Expósito J., Oliver F.J., de Almodóvar J.M.R.. Exosomes derived from mesenchymal stem cells enhance radiotherapy-induced cell death in tumor and metastatic tumor foci. Molecular Cancer. 15 August 2018. DOI: 10.1186/s12943-018-0867-0.

Impacto: 10.679. Cuartil: Q1 (1er decil)

Ahmad H., Requena T., Frejo L., Cobo M., Gallego-Martinez A., Martin F., Lopez-Escamez J.A., Bronstein A.M.. Clinical and functional characterization of a missense ELF2 variant in a CANVAS family. Frontiers in Genetics. 23 March 2018. DOI: 10.3389/fgene.2018.00085.

Impacto: 3.517. Cuartil: Q2

Gutierrez-Guerrero A., Sanchez-Hernandez S., Galvani G., Pinedo-Gomez J., Martin-Guerra R., Sanchez-Gilabert A., Aguilar-González A., Cobo M., Gregory P., Holmes M., Benabdellah K., Martin F.. Comparison of Zinc Finger Nucleases Versus CRISPR-Specific Nucleases for Genome Editing of the Wiskott-Aldrich Syndrome Locus. Human Gene Therapy. March 2018. DOI: 10.1089/hum.2017.047.

Impacto: 3.855. Cuartil: Q1

Abadía-Molina F., Morón-Calvente V., Baird S.D., Shamim F., Martín F., MacKenzie A.. Neuronal apoptosis inhibitory protein (NAIP) localizes to the cytokinetic machinery during cell division. Scientific Reports. 6 January 2017. DOI: 10.1038/srep39981.

Impacto: 4.122. Cuartil: Q1

Anderson P., Gonzalez-Rey E., O'Valle F., Martin F., Oliver F.J., Delgado M.. Allogeneic adipose-derived mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by regulating self-reactive T cell responses and dendritic cell function. Stem Cells International. 2017. DOI: 10.1155/2017/2389753.

Marin-Bañasco C., Benabdellah K., Melero-Jerez C., Oliver B., Pinto-Medel M.J., Hurtado-Guerrero I., de Castro F., Clemente D., Fernández O., Martin F., Leyva L., Suardíaz M.. Gene therapy with mesenchymal stem cells expressing IFN-ß ameliorates neuroinflammation in experimental models of multiple sclerosis. British Journal of Pharmacology. 2017. DOI: 10.1111/bph.13674.

Impacto: 6.81. Cuartil: Q1 (1er decil)

Benabdellah K., Munõz P., Cobo M., Gutierrez-Guerrero A., Sánchez-Hernández S., Garcia-Perez A., Anderson P., Carrillo-Gálvez A.B., Toscano M.G., Martin F.. Lent-On-Plus Lentiviral vectors for conditional expression in human stem cells. Scientific Reports. 17 November 2016. DOI: 10.1038/srep37289.

Impacto: 4.259. Cuartil: Q1

Martin F., Sánchez-Hernández S., Gutiérrez-Guerrero A., Pinedo-Gomez J., Benabdellah K.. Biased and unbiased methods for the detection of off-target cleavage by CRISPR/Cas9: An overview. International Journal of Molecular Sciences. 8 September 2016. DOI: 10.3390/ijms17091507.

Impacto: 3.226. Cuartil: Q2

Barriocanal-Casado E., Cueto-Ureña C., Benabdellah K., Gutiérrez-Guerrero A., Cobo M., Hidalgo-Gutiérrez A., Rodríguez-Sevilla J.J., Martín F., López L.C.. Gene therapy corrects mitochondrial dysfunction in hematopoietic progenitor cells and fibroblasts from Coq9R239X mice. PLoS ONE. June 2016. DOI: 10.1371/journal.pone.0158344.

Impacto: 2.806. Cuartil: Q1

García-Alegría E., Lafita-Navarro M.C., Aguado R., García-Gutiérrez L., Sarnataro K., Ruiz-Herguido C., Martín F., Bigas A., Canelles M., León J.. NUMB inactivation confers resistance to imatinib in chronic myeloid leukemia cells. Cancer Letters. May 28, 2016. DOI: 10.1016/j.canlet.2016.02.037.

Impacto: 6.375. Cuartil: Q1

Martin F., Gutierrez-Guerrero A., Sánchez S., Galvani G., Benabdellah K.. Genome editing: An alternative to retroviral vectors for Wiskott-Aldrich Syndrome (WAS) Gene Therapy?. Expert Opinion on Orphan Drugs. 3 March 2016. DOI: 10.1517/21678707.2016.1142870.

Impacto: 0.559. Cuartil: Q4

Toscano M.G., Muñoz P., Sánchez-Gilabert A., Cobo M., Benabdellah K., Anderson P., Ramos-Mejía V., Real P.J., Neth O., Molinos-Quintana A., Gregory P.D., Holmes M.C., Martin F.. Absence of WASp enhances hematopoietic and megakaryocytic differentiation in a human embryonic stem cell model. Molecular Therapy. 1 February 2016. DOI: 10.1038/mt.2015.196.

Impacto: 6.688. Cuartil: Q1 (1er decil)

Toscano M.G., Navarro-Montero O., Ayllon V., Ramos-Mejia V., Guerrero-Carreno X., Bueno C., Romero T., Lamolda M., Cobo M., Martin F., Menendez P., Real P.J.. SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. Molecular Therapy. 10 January 2015. DOI: 10.1038/mt.2014.196.

Impacto: 6.938. Cuartil: Q1 (1er decil)

Carrillo-Galvez A.B., Cobo M., Cuevas-Ocaña S., Gutiérrez-Guerrero A., Sánchez-Gilabert A., Bongarzone P., García-Pérez A., Muñoz P., Benabdellah K., Toscano M.G., Martín F., Anderson P.. Mesenchymal stromal cells express GARP/LRRC32 on their surface: Effects on their biology and immunomodulatory capacity. Stem Cells. 1 January 2015. DOI: 10.1002/stem.1821.

Impacto: 5.902. Cuartil: Q1 (1er decil)

Munõz-Fernández R., Prados A., Tirado-González I., Martín F., Abadiá A.C., Olivares E.G.. Contractile activity of human follicular dendritic cells. Immunology and Cell Biology. 11 November 2014. DOI: 10.1038/icb.2014.61.

Impacto: 4.147. Cuartil: Q1

Hernández-Cortés P., Toledo-Romero M.A., Delgado M., Sánchez-González C.E., Martin F., Galindo-Moreno P., O'Valle F.. Peripheral nerve reconstruction with epsilon-caprolactone conduits seeded with vasoactive intestinal peptide gene-transfected mesenchymal stem cells in a rat model. Journal of Neural Engineering. 1 August 2014. DOI: 10.1088/1741-2560/11/4/046024.

Impacto: 3.295. Cuartil: Q1

Escolano A., Martínez-Martínez S., Alfranca A., Urso K., Izquierdo H.M., Delgado M., Martín F., Sabio G., Sancho D., Gõmez-Del Arco P., Redondo J.M.. Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38. EMBO Journal. 16 May 2014. DOI: 10.1002/embj.201386369.

Impacto: 10.434. Cuartil: Q1 (1er decil)

Benabdellah K., Gutierrez-Guerrero A., Cobo M., Muñoz P., Martín F.. A chimeric HS4-SAR insulator (IS2) that prevents silencing and enhances expression of lentiviral vectors in pluripotent stem cells. PLoS ONE. 6 January 2014. DOI: 10.1371/journal.pone.0084268.

Impacto: 3.234. Cuartil: Q1

Anderson P., Carrillo-Gálvez A.B., García-Pérez A., Cobo M., Martín F.. CD105 (Endoglin)-Negative Murine Mesenchymal Stromal Cells Define a New Multipotent Subpopulation with Distinct Differentiation and Immunomodulatory Capacities. PLoS ONE. 4 October 2013. DOI: 10.1371/journal.pone.0076979.

Impacto: 3.534. Cuartil: Q1

Cobo M., Anderson P., Benabdellah K., Toscano M.G., Muñoz P., García-Pérez A., Gutierrez I., Delgado M., Martin F.. Mesenchymal stem cells expressing vasoactive intestinal peptide ameliorate symptoms in a model of chronic multiple sclerosis. Cell Transplantation. 2013. DOI: 10.3727/096368912X657404.

Impacto: 3.57. Cuartil: Q1

Toscano M.G., Anderson P., Muñoz P., Lucena G., Cobo M., Benabdellah K., Gregory P.D., Holmes M.C., Martin F.. Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: A human cellular model for Wiskott-Aldrich syndrome. DMM Disease Models and Mechanisms. March 2013. DOI: 10.1242/dmm.010652.

Impacto: 5.537. Cuartil: Q1 (1er decil)

Muñoz P., Toscano M.G., Real P.J., Benabdellah K., Cobo M., Bueno C., Ramos-Mejía V., Menendez P., Anderson P., Martín F.. Specific marking of hESCs-derived hematopoietic lineage by WAS-promoter driven lentiviral vectors. PLoS ONE. 14 June 2012. DOI: 10.1371/journal.pone.0039091.

Impacto: 3.73. Cuartil: Q1

Ramos-Mejía V., Fernández A.F., Ayllón V., Real P.J., Bueno C., Anderson P., Martín F., Fraga M.F., Menendez P.. Maintenance of human embryonic stem cells in mesenchymal stem cell-conditioned media augments hematopoietic specification. Stem Cells and Development. 10 June 2012. DOI: 10.1089/scd.2011.0400.

Impacto: 4.67. Cuartil: Q1

Tirado-González I., Muñoz-Fernández R., Prados A., Leno-Durán E., Martin F., Abadía-Molina A.C., Olivares E.G.. Apoptotic DC-SIGN+ cells in normal human decidua. Placenta. April 2012. DOI: 10.1016/j.placenta.2012.01.003.

Impacto: 3.117. Cuartil: Q1

Benabdellah K., Cobo M., Muñoz P., Toscano M.G., Martin F.. Development of an all-in-one lentiviral vector system based on the original TetR for the easy generation of Tet-on cell lines. PLoS ONE. 2011. DOI: 10.1371/journal.pone.0023734.

Impacto: 4.092. Cuartil: Q1

Romero Z., Torres S., Cobo M., Mũoz P., Unciti J.D., Martín F., Molina I.J.. A tissue-specific, activation-inducible, lentiviral vector regulated by human CD40L proximal promoter sequences. Gene Therapy. April 2011. DOI: 10.1038/gt.2010.144.

Impacto: 3.71. Cuartil: Q1

Toscano M.G., Romero Z., Mũoz P., Cobo M., Benabdellah K., Martin F.. Physiological and tissue-specific vectors for treatment of inherited diseases. Gene Therapy. February 2011. DOI: 10.1038/gt.2010.138.

Impacto: 3.71. Cuartil: Q1

Toscano M.G., Delgado M., Kong W., Martin F., Skarica M., Ganea D.. Dendritic cells transduced with lentiviral vectors expressing vip differentiate into vip-secreting tolerogenic-like DCs. Molecular Therapy. May 2010. DOI: 10.1038/mt.2009.293.

Impacto: 7.149. Cuartil: Q1 (1er decil)

Toscano M.G., Benabdellah K., Muñoz P., Frecha C., Cobo M., Martín F.. Was cDNA sequences modulate transgene expression of was promoter-driven lentiviral vectors. Human Gene Therapy. 1 November 2009. DOI: 10.1089/hum.2009.118.

Impacto: 4.202. Cuartil: Q1

MacÍas D., Oya R., Saniger L., Martín F., Luque F.. A lentiviral vector that activates latent human immunodeficiency virus-1 proviruses by the overexpression of tat and that kills the infected cells. Human Gene Therapy. 1 November 2009. DOI: 10.1089/hum.2009.059.

Impacto: 4.202. Cuartil: Q1

Romero Z., Toscano M.G., Unciti J.D., Molina I.J., Martín F.. Safer vectors for gene therapy of primary immunodeficiencies. Current Gene Therapy. 2009. DOI: 10.2174/156652309788921080.

Impacto: 4.852. Cuartil: Q1

Delgado M., Toscano M.G., Benabdellah K., Cobo M., O'Valle F., Gonzalez-Rey E., Martín F.. In vivo delivery of lentiviral vectors expressing vasoactive intestinal peptide complementary DNA as gene therapy for collagen-induced arthritis. Arthritis and Rheumatism. April 2008. DOI: 10.1002/art.23283.

Impacto: 6.787. Cuartil: Q1

Toscano M.G., Frecha C., Benabdellah K., Cobo M., Blundell M., Thrasher A.J., García-Olivares E., Molina I.J., Martin F.. Hematopoietic-specific lentiviral vectors circumvent cellular toxicity due to ectopic expression of Wiskott-Aldrich syndrome protein. Human Gene Therapy. 1 February 2008. DOI: 10.1089/hum.2007.098.

Impacto: 4.104. Cuartil: Q1

Frecha C., Toscano M.G., Costa C., Saez-Lara M.J., Cosset F.L., Verhoeyen E., Martin F.. Improved lentiviral vectors for Wiskott-Aldrich syndrome gene therapy mimic endogenous expression profiles throughout haematopoiesis. Gene Therapy. June 2008. DOI: 10.1038/gt.2008.20.

Impacto: 4.492. Cuartil: Q1

Sáez-Lara M.J., Frecha C., Martín F., Abadía F., Toscano M., Gil A., Fontana L.. Transplantation of human CD34+ stem cells from umbilical cord blood to rats with thioacetamide-induced liver cirrhosis. Xenotransplantation. November 2006. DOI: 10.1111/j.1399-3089.2006.00344.x.

Impacto: 1.777. Cuartil: N/D

Muñoz-Fernández R., Blanco F., Frecha C., Martín F., Kimatrai M., Abadía-Molina A., García-Pacheco J., Olivares E.. Follicular dendritic cells are related to bone marrow stromal cell progenitors and to myofibroblasts. Journal of Immunology. 1 July 2006. DOI: 10.4049/jimmunol.177.1.280.

Impacto: 6.293. Cuartil: N/D

Kimatrai M., Blanco O., Muñoz-Fernández R., Tirado I., Martin F., Abadía-Molina A., Olivares E.. Contractile activity of human decidual stromal cells. II. Effect of interleukin-10. Journal of Clinical Endocrinology and Metabolism. November 2005. DOI: 10.1210/jc.2005-0047.

Impacto: 6.02. Cuartil: N/D

Chan L., Nesbeth D., MacKey T., Galea-Lauri J., Gäken J., Martin F., Collins M., Mufti G., Farzaneh F., Darling D.. Conjugation of lentivirus to paramagnetic particles via nonviral proteins allows efficient concentration and infection of primary acute myeloid leukemia cells. Journal of Virology. October 2005. DOI: 10.1128/JVI.79.20.13190-13194.2005.

Impacto: 5.178. Cuartil: N/D

Martín F., Toscano M.G., Blundell M., Frecha C., Srivastava G.K., Santamaría M., Thrasher A.J., Molina I.J.. Lentiviral vectors transcriptionally targeted to hematopoietic cells by WASP gene proximal promoter sequences. Gene Therapy. April 2005. DOI: 10.1038/sj.gt.3302457.

Impacto: 4.836. Cuartil: N/D

Toscano M., Frecha C., Ortega C., Santamaría M., Martín F., Molina I.. Efficient lentiviral transduction of herpesvirus saimiri immortalized T cells as a model for gene therapy in primary immunodeficiencies. Gene Therapy. June 2004. DOI: 10.1038/sj.gt.3302259.

Impacto: 4.977. Cuartil: N/D

Chowdhury S., Chester K.A., Bridgewater J., Collins M.K., Martin F.. Efficient retroviral vector targeting of carcinoembryonic antigen-positive tumors. Molecular Therapy. January 2004. DOI: 10.1016/j.ymthe.2003.10.004.

Impacto: 5.204. Cuartil: N/D

Ikeda Y., Takeuchi Y., Martin F., Cosset F.L., Mitrophanous K., Collins M.. Continuous high-titer HIV-1 vector production. Nature Biotechnology. 1 May 2003. DOI: 10.1038/nbt815.

Impacto: 17.721. Cuartil: N/D

Martin F., Chowdhury S., Neil S.J., Chester K.A., Cosset F.L., Collins M.K.. Targeted retroviral infection of tumor cells by receptor cooperation. Journal of Virology. February 2003. DOI: 10.1128/JVI.77.4.2753-2756.2003.

Impacto: 5.225. Cuartil: N/D

González J.A., González-Vila F.J., Almendros G., Zancada M.C., Polvillo O., Martín F.. Preferential accumulation of selectively preserved biomacromolecules in the humus fractions from a peat deposit as seen by analytical pyrolysis and spectroscopic techniques. Journal of Analytical and Applied Pyrolysis. August 2003. DOI: 10.1016/S0165-2370(03)00069-X.

Impacto: 1.463. Cuartil: N/D

Martín F., Chowdhury S., Neil S., Phillipps N., Collins M.. Envelope-targeted retrovirus vectors transduce melanoma xenografts but not spleen or liver. Molecular Therapy. 2002. DOI: 10.1006/mthe.2002.0550.

Impacto: 6.275. Cuartil: N/D

González-Vila F.J., Tinoco P., Almendros G., Martin F.. Pyrolysis-GC-MS analysis of the formation and degradation stages of charred residues from lignocellulosic biomass. Journal of Agricultural and Food Chemistry. 2001. DOI: 10.1021/jf0006325.

Neil S., Martin F., Ikeda Y., Collins M.. Postentry restriction to human immunodeficiency virus-based vector transduction in human monocytes. Journal of Virology. 2001. DOI: 10.1128/JVI.75.12.5448-5456.2001.

Martin F., Almendros G., González-Vila F.J., Verdejo T.. Experimental reappraisal of flash pyrolysis and low-temperature thermally assisted hydrolysis and methylation using tetramethylammonium hydroxide for the molecular characterization of humic acids. Journal of Analytical and Applied Pyrolysis. November 2001. DOI: 10.1016/S0165-2370(01)00130-9.

Mercado I., García-Calderón N., Ibáñez A., Martin F.. Composition of soil lipids in two, chinampas agroecosystems from Xochimilco and Tlahuac municipalities, Mexico. Communications in Soil Science and Plant Analysis. 2000. DOI: 10.1080/00103620009370494.

Bautista J.M., González-Vila F.J., Martín F., Del Rio J.C., Gutierrez A., Verdejo T., Gustavo González A.. Supercritical-carbon-dioxide extraction of lipids from a contaminated soil. Journal of Chromatography A. 11 June 1999. DOI: 10.1016/S0021-9673(99)00334-9.

Hatziioannou T., Delahaye E., Martin F., Russell S., Cosset F.. Retroviral display of functional binding domains fused to the amino terminus of influenza hemagglutinin. Human Gene Therapy. 10 June 1999. DOI: 10.1089/10430349950017860.

Del Río J.C., Gutiérrez A., González-Vila F.J., Martín F.. Application of pyrolysis-gas chromatography-mass spectrometry to the analysis of pitch deposits and synthetic polymers in pulp and pulp mills. Journal of Analytical and Applied Pyrolysis. February 1999. DOI: 10.1016/S0165-2370(98)00099-0.

González-Vila F.J., Almendros G., Del Rio J.C., Martín F., Gutiérrez A., Romero J.. Ease of delignification assessment of wood from different Eucalyptus species by pyrolysis (TMAH)-GC/MS and CP/MAS 13C-NMR spectrometry. Journal of Analytical and Applied Pyrolysis. February 1999. DOI: 10.1016/S0165-2370(98)00097-7.