RED TERAV - Investigadores

Investigadores

Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Investigadores
Publicaciones

África González Fernández

Investigador principal

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Alba Pensado López

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Alberto Jiménez Lomo

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

André Pérez Potti

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Begoña Graña Suárez

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Christian Sánchez Espinel

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Fernando Torres Andon

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Israel Nieto Gañán

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Joel Verísimo García

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

José Gómez Rial

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Lorena Boquete Vilariño

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

María del Carmen Albo López

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

María José Alonso Fernández

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

María Rosario García Campelo

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Marta Sonia González Pérez

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Martín Emilio Lázaro Quintela

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Rafael López López

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Raquel Almuiña González

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Ricardo Rojo Amigo

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Rosana Simón Vázquez

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Sofía Silva Díaz

Investigador colaborador

Grupo de Investigación: Instituto de Investigación Sanitaria Galicia Sur (IISGS)

Andón F.T., Rosales Sánchez A., Pensado-López A., García-Campelo R., Takimoto C.H.. Engineering macrophages for effective and safe targeting of CD47 cancer cells in the tumor microenvironment. Journal for Immunotherapy of Cancer. February 2026. DOI: 10.1136/jitc-2025-014457.

Impacto: 10.6. Cuartil: Q1 (1er decil)

Pensado-López A., Sánchez A.R., Andón F.T.. Myeloid Cell Therapies. Springer Handbooks. 2026. DOI: 10.1007/978-3-032-01636-2_25.

Sacristan Santos V., Pensado-López A., García-Campelo R., Antolin Novoa S., Señaris Rodriguez R., Andón F.T.. Reprogramming tumor-associated macrophages using STING or TLR agonists: A promising strategy to enhance immunotherapy in hormone-dependent cancers. Journal for Immunotherapy of Cancer. 15 May 2025. DOI: 10.1136/jitc-2024-010950.

Impacto: 10.6. Cuartil: Q1 (1er decil)

Blanco A.F., Lou G., Pensado-López A., Ummarino A., Andón F.T., Crecente-Campo J., Alonso M.J.. Controlled co-delivery of anti-inflammatory drugs from bilayer polymer films coating a meniscus implant. Drug Delivery and Translational Research. 2025. DOI: 10.1007/s13346-025-01942-5.

Impacto: 5.5. Cuartil: Q1 (1er decil)

Pensado-López A., Ummarino A., Khan S., Guildford A., Allan I.U., Santin M., Chevallier N., Varaillon E., Kon E., Allavena P., Torres Andón F.. Synthetic peptides of IL-1Ra and HSP70 have anti-inflammatory activity on human primary monocytes and macrophages: Potential treatments for inflammatory diseases. Nanomedicine Nanotechnology Biology and Medicine. January 2024. DOI: 10.1016/j.nano.2023.102719.

Impacto: 4.6. Cuartil: Q2

Ummarino A., Pensado-López A., Migliore R., Alcaide-Ruggiero L., Calà N., Caputo M., Gambaro F.M., Anfray C., Ronzoni F.L., Kon E., Allavena P., Torres Andón F.. An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists. European Journal of Immunology. December 2023. DOI: 10.1002/eji.202350507.

Impacto: 4.5. Cuartil: Q2

Fernández-Mariño I., Anfray C., Crecente-Campo J., Maeda A., Ummarino A., Teijeiro-Valiño C., Blanco-Martinez D., Mpambani F., Poul L., Devalliere J., Germain M., Correa J., Fernandez-Villamarin M., Allavena P., Fernandez-Megia E., Alonso M.J., Andón F.T.. Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor-associated macrophages. Drug Delivery and Translational Research. July 2023. DOI: 10.1007/s13346-022-01265-9.

Impacto: 5.7. Cuartil: Q1

Anfray C., Ummarino A., Calvo A., Allavena P., Torres Andón F.. In Vivo Analysis of Tumor-Associated Macrophages in the Tumor Microenvironment. Methods in Molecular Biology. 2023. DOI: 10.1007/978-1-0716-2914-7_7.

Anfray C., Varela C.F., Ummarino A., Maeda A., Sironi M., Gandoy S., Brea J., Loza M.I., León S., Calvo A., Correa J., Fernandez-Megia E., Alonso M.J., Allavena P., Crecente-Campo J., Andón F.T.. Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors. Frontiers in Immunology. 2023. DOI: 10.3389/fimmu.2023.1334800.

Impacto: 5.7. Cuartil: Q1

Ummarino A., Anfray C., Maeda A., Andón F.T., Allavena P.. In Vitro Methods to Evaluate Macrophage Polarization and Function in Cancer. Methods in Molecular Biology. 2023. DOI: 10.1007/978-1-0716-2914-7_6.

Andón F.T., Leon S., Ummarino A., Redin E., Allavena P., Serrano D., Anfray C., Calvo A.. Innate and Adaptive Responses of Intratumoral Immunotherapy with Endosomal Toll-Like Receptor Agonists. Biomedicines. July 2022. DOI: 10.3390/biomedicines10071590.

Impacto: 4.7. Cuartil: Q1

Andón F.T., Bondarenko O.. Recent discoveries in nanoparticle–macrophage interactions: In vitro models for nanosafety testing and novel nanomedical approaches for immunotherapy. Nanomaterials. November 2021. DOI: 10.3390/nano11112971.

Impacto: 5.719. Cuartil: Q1

Dacoba T.G., Anthiya S., Berrecoso G., Fernández-Mariño I., Fernández-Varela C., Crecente-Campo J., Teijeiro-Osorio D., Torres Andón F., Alonso M.J.. Nano-Oncologicals: A Tortoise Trail Reaching New Avenues. Advanced Functional Materials. October 26, 2021. DOI: 10.1002/adfm.202009860.

Impacto: 19.924. Cuartil: Q1 (1er decil)

Anfray C., Mainini F., Digifico E., Maeda A., Sironi M., Erreni M., Anselmo A., Ummarino A., Gandoy S., Expósito F., Redrado M., Serrano D., Calvo A., Martens M., Bravo S., Mantovani A., Allavena P., Andón F.T.. Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity. Journal for Immunotherapy of Cancer. 16 September 2021. DOI: 10.1136/jitc-2021-002408.

Impacto: 12.469. Cuartil: Q1 (1er decil)

Gambaro F.M., Ummarino A., Andón F.T., Ronzoni F., Di Matteo B., Kon E.. Drug delivery systems for the treatment of knee osteoarthritis: A systematic review of in vivo studies. International Journal of Molecular Sciences. 1 September 2021. DOI: 10.3390/ijms22179137.

Impacto: 6.208. Cuartil: Q1

Sieiro C., Pichardo-Gallardo Á., Areal-Hermida L., Almuiña-González R., Villa T.G.. Parasporal crystal toxins in bacillus thuringiensis. Developmental Biology in Prokaryotes and Lower Eukaryotes. 31 July 2021. DOI: 10.1007/978-3-030-77595-7_4.

Pensado-López A., Fernández-Rey J., Reimunde P., Crecente-Campo J., Sánchez L., Torres Andón F.. Zebrafish models for the safety and therapeutic testing of nanoparticles with a focus on macrophages. Nanomaterials. July 2021. DOI: 10.3390/nano11071784.

Impacto: 5.719. Cuartil: Q1

Allavena P., Anfray C., Ummarino A., Andón F.T.. Therapeutic manipulation of tumor-associated macrophages: Facts and hopes from a clinical and translational perspective. Clinical Cancer Research. June 2021. DOI: 10.1158/1078-0432.CCR-20-1679.

Impacto: 13.801. Cuartil: Q1 (1er decil)

Keshavan S., Andón F.T., Gallud A., Chen W., Reinert K., Tran L., Fadeel B.. Profiling of sub‐lethal in vitro effects of multi‐walled carbon nanotubes reveals changes in chemokines and chemokine receptors. Nanomaterials. April 2021. DOI: 10.3390/nano11040883.

Impacto: 5.719. Cuartil: Q1

Reimunde P., Pensado‐lópez A., Crende M.C., Iglesias V.L., Sánchez L., Torrecilla‐parra M., Ramírez C.M., Anfray C., Andón F.T.. Cellular and molecular mechanisms underlying glioblastoma and zebrafish models for the discovery of new treatments. Cancers. 1 March 2021. DOI: 10.3390/cancers13051087.

Impacto: 6.575. Cuartil: Q1

Belgiovine C., Digifico E., Anfray C., Ummarino A., Andón F.T.. Targeting tumor-associated macrophages in anti-cancer therapies: Convincing the traitors to do the right thing. Journal of Clinical Medicine. October 2020. DOI: 10.3390/jcm9103226.

Impacto: 4.241. Cuartil: Q1

Sieiro C., Areal‐hermida L., Pichardo‐gallardo Á., Almuiña‐gonzález R., de Miguel T., Sánchez S., Sánchez‐pérez Á., Villa T.G.. A hundred years of bacteriophages: Can phages replace antibiotics in agriculture and aquaculture?. Antibiotics. August 2020. DOI: 10.3390/antibiotics9080493.

Impacto: 4.639. Cuartil: Q2

Ummarino A., Gambaro F.M., Kon E., Andón F.T.. Therapeutic manipulation of macrophages using nanotechnological approaches for the treatment of osteoarthritis. Nanomaterials. August 2020. DOI: 10.3390/nano10081562.

Impacto: 5.076. Cuartil: Q1

Dacoba T.G., Anfray C., Mainini F., Allavena P., Alonso M.J., Torres Andón F., Crecente-Campo J.. Arginine-Based Poly(I:C)-Loaded Nanocomplexes for the Polarization of Macrophages Toward M1-Antitumoral Effectors. Frontiers in Immunology. 7 July 2020. DOI: 10.3389/fimmu.2020.01412.

Impacto: 7.561. Cuartil: Q1

Anfray C., Mainini F., Andón F.T.. Nanoparticles for immunotherapy. Frontiers of Nanoscience. 2020. DOI: 10.1016/B978-0-08-102828-5.00011-5.

Anfray C., Ummarino A., Andón F.T., Allavena P.. Current strategies to target tumor-associated-macrophages to improve anti-tumor immune responses. Cells. January 2020. DOI: 10.3390/cells9010046.

Impacto: 6.6. Cuartil: Q2

Maeda A., Digifico E., Andon F.T., Mantovani A., Allavena P.. Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor-conditioned macrophages. European Journal of Immunology. May 2019. DOI: 10.1002/eji.201847888.

Impacto: 4.404. Cuartil: Q2

Mukherjee S.P., Bondarenko O., Kohonen P., Andón F.T., Brzicová T., Gessner I., Mathur S., Bottini M., Calligari P., Stella L., Kisin E., Shvedova A., Autio R., Salminen-Mankonen H., Lahesmaa R., Fadeel B.. Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors. Scientific Reports. 1 December 2018. DOI: 10.1038/s41598-018-19521-9.

Impacto: 4.011. Cuartil: Q1

Martens M., Verbruggen T., Nymark P., Grafström R., Burgoon L.D., Aladjov H., Andón F.T., Evelo C.T., Willighagen E.L.. Introducing wikipathways as a data-source to support adverse outcome pathways for regulatory risk assessment of chemicals and nanomaterials. Frontiers in Genetics. 2018. DOI: 10.3389/fgene.2018.00661.

Impacto: 3.517. Cuartil: Q2

Andón F.T., Digifico E., Maeda A., Erreni M., Mantovani A., Alonso M.J., Allavena P.. Targeting tumor associated macrophages: The new challenge for nanomedicine. Seminars in Immunology. December 2017. DOI: 10.1016/j.smim.2017.09.004.

Impacto: 7.206. Cuartil: Q1

Farrera C., Torres Andón F., Feliu N.. Carbon Nanotubes as Optical Sensors in Biomedicine. ACS Nano. 28 November 2017. DOI: 10.1021/acsnano.7b06701.

Impacto: 13.709. Cuartil: Q1 (1er decil)

Andón F.T., Mukherjee S.P., Gessner I., Wortmann L., Xiao L., Hultenby K., Shvedova A.A., Mathur S., Fadeel B.. Hollow carbon spheres trigger inflammasome-dependent IL-1β secretion in macrophages. Carbon. 1 March 2017. DOI: 10.1016/j.carbon.2016.11.049.

Impacto: 7.082. Cuartil: Q1

Bhattacharya K., El-Sayed R., Andón F., Mukherjee S., Gregory J., Li H., Zhao Y., Seo W., Fornara A., Brandner B., Toprak M., Leifer K., Star A., Fadeel B.. Erratum: Lactoperoxidase-mediated degradation of single-walled carbon nanotubes in the presence of pulmonary surfactant (Carbon (2015) 91 (506-517)). Carbon. 11 October 2015. DOI: 10.1016/j.carbon.2015.09.004.

Impacto: 6.198. Cuartil: Q1 (1er decil)

Torres Andón F., Alonso M.J.. Nanomedicine and cancer immunotherapy - Targeting immunosuppressive cells. Journal of Drug Targeting. 14 September 2015. DOI: 10.3109/1061186X.2015.1073295.

Impacto: 2.821. Cuartil: Q2

Bhattacharya K., El-Sayed R., Andón F.T., Mukherjee S.P., Gregory J., Li H., Zhao Y., Seo W., Fornara A., Brandner B., Toprak M.S., Leifer K., Star A., Fadeel B.. Lactoperoxidase-mediated degradation of single-walled carbon nanotubes in the presence of pulmonary surfactant. Carbon. 30 May 2015. DOI: 10.1016/j.carbon.2015.05.022.

Impacto: 6.198. Cuartil: Q1 (1er decil)

Farcal L., Andón F.T., Di Cristo L., Rotoli B.M., Bussolati O., Bergamaschi E., Mech A., Hartmann N.B., Rasmussen K., Riego-Sintes J., Ponti J., Kinsner-Ovaskainen A., Rossi F., Oomen A., Bos P., Chen R., Bai R., Chen C., Rocks L., Fulton N., Ross B., Hutchison G., Tran L., Mues S., Ossig R., Schnekenburger J., Campagnolo L., Vecchione L., Pietroiusti A., Fadeel B.. Comprehensive in vitro toxicity testing of a panel of representative oxide nanomaterials: First steps towards an intelligent testing strategy. Plos One. 21 May 2015. DOI: 10.1371/journal.pone.0127174.

Impacto: 3.057. Cuartil: Q1

Nicolini F., Burmistrova O., Marrero M.T., Torres F., Hernández C., Quintana J., Estévez F.. Induction of G2/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells. Molecular Carcinogenesis. 1 December 2014. DOI: 10.1002/mc.22055.

Impacto: 4.808. Cuartil: Q1

Farrera C., Bhattacharya K., Lazzaretto B., Andón F., Hultenby K., Kotchey G., Star A., Fadeel B.. Extracellular entrapment and degradation of single-walled carbon nanotubes. Nanoscale. 21 June 2014. DOI: 10.1039/c3nr06047k.

Impacto: 7.394. Cuartil: Q1 (1er decil)

Bhattacharya K., Andón F.T., El-Sayed R., Fadeel B.. Mechanisms of carbon nanotube-induced toxicity: Focus on pulmonary inflammation. Advanced Drug Delivery Reviews. December 2013. DOI: 10.1016/j.addr.2013.05.012.

Impacto: 12.707. Cuartil: Q1 (1er decil)

Andón F.T., Kapralov A.A., Yanamala N., Feng W., Baygan A., Chambers B.J., Hultenby K., Ye F., Toprak M.S., Brandner B.D., Fornara A., Klein-Seetharaman J., Kotchey G.P., Star A., Shvedova A.A., Fadeel B., Kagan V.E.. Biodegradation of single-walled carbon nanotubes by eosinophil peroxidase. Small Weinheim an Der Bergstrasse Germany. 26 August 2013. DOI: 10.1002/smll.201202508.

Andõn F.T., Kapralov A.A., Yanamala N., Feng W., Baygan A., Chambers B.J., Hultenby K., Ye F., Toprak M.S., Brandner B.D., Fornara A., Klein-Seetharaman J., Kotchey G.P., Star A., Shvedova A.A., Fadeel B., Kagan V.E.. Biodegradation of single-walled carbon nanotubes by eosinophil peroxidase. Small. 26 August 2013. DOI: 10.1002/smll.201202508.

Impacto: 7.514. Cuartil: Q1 (1er decil)

Andón F., Fadeel B.. Programmed cell death: Molecular mechanisms and implications for safety assessment of nanomaterials. Accounts of Chemical Research. 19 March 2013. DOI: 10.1021/ar300020b.

Impacto: 24.348. Cuartil: Q1 (1er decil)

Andón F.T., Pazinatto D.B., Fadeel B.. Research Highlights: Towards the clinic: Intelligent design of nanomedicines for cancer treatment. Nanomedicine. September 2012. DOI: 10.2217/nnm.12.113.

Impacto: 5.26. Cuartil: Q1 (1er decil)

Torres F., Quintana J., Estévez F.. 5,7,3'-trihydroxy-3,4'-dimethoxyflavone inhibits the tubulin polymerization and activates the sphingomyelin pathway. Molecular Carcinogenesis. February 2011. DOI: 10.1002/mc.20693.

Impacto: 3.164. Cuartil: Q2

Torres F., Quintana J., Estévez F.. 5,7,3′-trihydroxy-3,4′-dimethoxyflavone-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway. Molecular Carcinogenesis. May 2010. DOI: 10.1002/mc.20619.

Impacto: 3.265. Cuartil: Q2

Triana J., Eiroa J.L., Ortega J.J., León F., Brouard I., Torres F., Quintana J., Estévez F., Bermejo J.. Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities. Journal of Natural Products. 26 December 2008. DOI: 10.1021/np800474v.

Impacto: 2.843. Cuartil: Q1

Torres F., Quintana J., Cabrera J., Loro J.F., León F., Bermejo J., Estévez F.. Induction of G2-M phase arrest and apoptosis by α-methylene-γ-butyrolactones in human leukemia cells. Cancer Letters. 28 September 2008. DOI: 10.1016/j.canlet.2008.04.028.

Impacto: 3.504. Cuartil: Q2

Torres F., Quintana J., Díaz J.G., Carmona A.J., Estévez F.. Trifolin acetate-induced cell death in human leukemia cells is dependent on caspase-6 and activates the MAPK pathway. Apoptosis. May 2008. DOI: 10.1007/s10495-008-0202-0.

Impacto: 3.971. Cuartil: Q2

Hernández J., León F., Brouard I., Torres F., Rubio S., Quintana J., Estévez F., Bermejo J.. Synthesis of novel spirostanic saponins and their cytotoxic activity. Bioorganic and Medicinal Chemistry. 15 February 2008. DOI: 10.1016/j.bmc.2007.10.089.

Impacto: 3.075. Cuartil: Q2

León F., Brouard I., Torres F., Quíntana J., Rivera A., Estévez F., Bermejo J.. A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells. Chemistry and Biodiversity. 2008. DOI: 10.1002/cbdv.200890002.

Impacto: 1.659. Cuartil: Q3

Díaz J., Carmona A., Fernando Torres A., Quintana J., Estévez F., Herz W.. Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana. Planta Medica. 2008. DOI: 10.1055/s-2008-1034278.

Impacto: 1.96. Cuartil: Q3

León F., Brouard I., Rivera A., Torres F., Rubio S., Quintana J., Estévez F., Bermejo J.. Isolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells. Journal of Medicinal Chemistry. 21 September 2006. DOI: 10.1021/jm0605334.

Impacto: 5.115. Cuartil: N/D