RED TERAV - Investigadores

Investigadores

Instituo de Investigación Hospital La Paz (IdiPAZ). Madrid.

Inmunoterapia Celular (células CAR)

Investigadores
Publicaciones

Carmen Mestre Durán

Investigador colaborador

Grupo de Investigación: Instituo de Investigación Hospital La Paz (IdiPAZ). Madrid.

Cristina Aguirre Portolés

Investigador colaborador

Grupo de Investigación: Instituo de Investigación Hospital La Paz (IdiPAZ). Madrid.

Cristina Ferreras Puente

Investigador colaborador

Grupo de Investigación: Instituo de Investigación Hospital La Paz (IdiPAZ). Madrid.

JORDI MINGUILLÓN PEDREÑO

Investigador colaborador

Grupo de Investigación: Instituo de Investigación Hospital La Paz (IdiPAZ). Madrid.

Patricia Rodriguez Solana

Investigador colaborador

Grupo de Investigación: Instituo de Investigación Hospital La Paz (IdiPAZ). Madrid.

Hernández-Blanco C., Al-Akioui-Sanz K., Herrera L., Aguirre-Portolés C., Lozano-Ojalvo D., Pérez-Rodriguez L., Cano-Ochando J., Guerra-García P., Martín-Quirós A., Vicario J.L., Santos S., Pérez-Vaquero M.Á., Vesga M.Á., Borobia A.M., Carcas A.J., Balas A., Moreno M.Á., Pérez de Diego R., Gasior M., Soria B., Eguizabal C., Pérez-Martínez A.. The phase I RELEASE clinical trial to evaluate the safety of NK cells in COVID-19. iScience. 21 February 2025. DOI: 10.1016/j.isci.2024.111698.

Impacto: 4.6. Cuartil: Q1

Ramírez M.J., Pujol R., Minguillón J., Bogliolo M., Persico I., Cavero D., de la Cal A., Río P., Navarro S., Casado J.A., Bailador A., de la Fuente A.S., de Heredia M.L., Almazán F., Antelo M.L., Argilés B., Badell I., Baragaño M., Beléndez C., Bermúdez M., Bernués M., Buedo M.I., Carrasco E., Català A., Costa D., Cuesta I., Fernandez-Delgado R., Fernández-Teijeiro A., Figuera Á., García M., Gondra A., González M., Muñiz S.G., Hernández-Rodríguez I., Ibañez F., Kelleher N.J., Lendínez F., López M., López-Almaraz R., Marchante I., Mendoza C., Nieto J., Ojeda E., Payán-Pernía S., Peláez I., de Soto I.P., Portugal R., Ramos-Arroyo M.A., Regueiro A., Rodríguez A., Rosell J., Saez R., Sánchez J., Sánchez M., Senent M., Tapia M., Trujillo-Quintero J.P., Vagace J.M., Verdú-Amorós J., Verdugo V., Vidales I., Villarreal J., Díaz-de-Heredia C., Sevilla J., Bueren J.A., Surrallés J.. Prognostic significance of mutation type and chromosome fragility in Fanconi anemia. American Journal of Hematology. February 2025. DOI: 10.1002/ajh.27520.

Impacto: 10.1. Cuartil: Q1 (1er decil)

Camps-Fajol C., Cavero D., Minguillón J., Surrallés J.. Targeting protein-protein interactions in drug discovery: Modulators approved or in clinical trials for cancer treatment. Pharmacological Research. January 2025. DOI: 10.1016/j.phrs.2024.107544.

Impacto: 9.1. Cuartil: Q1 (1er decil)

Felgueres M.J., Esteso G., García-Jiménez Á.F., Dopazo A., Aguiló N., Mestre-Durán C., Martínez-Piñeiro L., Pérez-Martínez A., Reyburn H.T., Valés-Gómez M.. BCG priming followed by a novel interleukin combination activates Natural Killer cells to selectively proliferate and become anti-tumour long-lived effectors. Scientific Reports. December 2024. DOI: 10.1038/s41598-024-62968-2.

Impacto: 3.8. Cuartil: Q1

Gasior Kabat M., Li Y., Galán V., Mozo Y., Sisinni L., Bueno-Sánchez D., Corral D., Naik S., Echecopar C., Aguirre-Portolés C., Al-Akioui-Sanz K., De Paz R., Marcos A., Romero A.B., Talleur A., Yuste V.J., Triplett B., Pérez-Martínez A.. Safety and Efficacy of High-Dose Memory CD45RO+ Donor Lymphocyte Infusion in Pediatric Recipients after Hematopoietic Stem Cell Transplantation. Cytotherapy. December 2024. DOI: 10.1016/j.jcyt.2024.07.007.

Impacto: 3.7. Cuartil: Q1

Sanz-Flores M., Ruiz-Torres M., Aguirre-Portolés C., El Bakkali A., Salvador-Barberó B., Villarroya-Beltri C., Ortega S., Megías D., Gerlich D.W., Álvarez-Fernández M., Malumbres M.. PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome individualization during mitosis. Cell Reports. 23 July 2024. DOI: 10.1016/j.celrep.2024.114494.

Impacto: 7.5. Cuartil: Q1

Martín-Antonio B., Blanco B., González-Murillo Á., Hidalgo L., Minguillón J., Pérez-Chacón G., Fernández L., Bareke H., París-Muñoz A., Mañas A., Aguirre-Portolés C., Navarro-Zapata A., Mestre-Durán C., Ibáñez-Navarro M., Clares-Villa L., Naharro S., Perez-Martinez A., Aldea M., Gaibar M., Ruiz-Navarro J., Izquierdo M., Zapata J.M., Tarifa E.E., Serrano-López J., Llamas-Sillero P., Murillo Á.G., Sánchez E.G., Martínez J.G., Simón A.R.S., Herrero B., Aguilera G.G., Morera B.H., Orellana M.R., Blanco-Durango B., Jiménez-Reinoso A., Lázaro-Gorines R., Zagorac I., Galisteo A.T., Ramirez-Fernández Á., Díez-Alonso L., Dominguez-Alonso C., Erce-Llamazares A., Hangiu O., Pérez L.R., Rosel M.G., Tudela A.S., Arroyo-Ródena J., Álvarez-Vallina L., Milla M.Á.R., Rodríguez P.G., Crespo B.S., García-Castro J.. Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations. Frontiers in Immunology. 2024. DOI: 10.3389/fimmu.2024.1386856.

Impacto: 5.7. Cuartil: Q1

Ferreras C., Hernández-Blanco C., Martín-Quirós A., Al-Akioui-Sanz K., Mora-Rillo M., Ibáñez F., Díaz-Almirón M., Cano-Ochando J., Lozano-Ojalvo D., Jiménez-González M., Goterris R., Sánchez-Zapardiel E., de Paz R., Guerra-García P., Queiruga-Parada J., Molina P., Briones M.L., Ruz-Caracuel B., Borobia A.M., Carcas A.J., Planelles D., Vicario J.L., Moreno M.Á., Balas A., Llano M., Llorente A., del Balzo Á., Cañada C., García M.Á., Calvin M.E., Arenas I., Pérez de Diego R., Eguizábal C., Soria B., Solano C., Pérez-Martínez A.. Results of phase 2 randomized multi-center study to evaluate the safety and efficacy of infusion of memory T cells as adoptive therapy in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia and/or lymphopenia (RELEASE NCT04578210). Cytotherapy. January 2024. DOI: 10.1016/j.jcyt.2023.10.002.

Impacto: 3.7. Cuartil: Q1

Sánchez-Cazorla E., González-Atienza C., López-Vázquez A., Arruti N., Nieves-Moreno M., Noval S., Mena R., Rodríguez-Jiménez C., Rodríguez-Solana P., González-Iglesias E., Guerrero-Carretero M., D’Anna Mardero O., Coca-Robinot J., Acal J.C., Blasco J., Castañeda C., Fraile Maya J., Del Pozo Á., Gómez-Pozo M.V., Montaño V.E.F., Dios-Blázquez L.D., Rodríguez-Antolín C., Gómez-Cano M.d.L.Á., Delgado-Mora L., Vallespín E.. Whole-Exome Sequencing of 21 Families: Candidate Genes for Early-Onset High Myopia. International Journal of Molecular Sciences. November 2023. DOI: 10.3390/ijms242115676.

Impacto: 4.9. Cuartil: Q1

González-Atienza C., Sánchez-Cazorla E., Villoldo-Fernández N., del Hierro A., Boto A., Guerrero-Carretero M., Nieves-Moreno M., Arruti N., Rodríguez-Solana P., Mena R., Rodríguez-Jiménez C., Rosa-Pérez I., Acal J.C., Blasco J., Naranjo-Castresana M., Ruz-Caracuel B., Montaño V.E.F., Ortega Patrón C., Rubio-Martín M.E., García-Fernández L., Rikeros-Orozco E., Gómez-Cano M.d.L.Á., Delgado-Mora L., Noval S., Vallespín E.. Whole-Exome Sequencing of 24 Spanish Families: Candidate Genes for Non-Syndromic Pediatric Keratoconus. Genes. October 2023. DOI: 10.3390/genes14101838.

Impacto: 2.8. Cuartil: Q2

García-Solís B., Van Den Rym A., Martinez-Martínez L., Franco T., Pérez-Caraballo J.J., Markle J., Cubillos-Zapata C., Marín A.V., Recio M.J., Regueiro J.R., Navarro-Zapata A., Mestre-Durán C., Ferreras C., Martín Cotázar C., Mena R., de la Calle-Fabregat C., López-Lera A., Fernández Arquero M., Pérez-Martínez A., López-Collazo E., Sánchez-Ramón S., Casanova J.L., Martínez-Barricarte R., de la Calle-Martín O., Pérez de Diego R.. Inherited human ezrin deficiency impairs adaptive immunity. Journal of Allergy and Clinical Immunology. October 2023. DOI: 10.1016/j.jaci.2023.05.022.

Impacto: 11.4. Cuartil: Q1 (1er decil)

Rodríguez-Solana P., Arruti N., Nieves-Moreno M., Mena R., Rodríguez-Jiménez C., Guerrero-Carretero M., Acal J.C., Blasco J., Peralta J.M., Del Pozo Á., Montaño V.E.F., Dios-Blázquez L.D., Fernández-Alcalde C., González-Atienza C., Sánchez-Cazorla E., Gómez-Cano M.d.L.Á., Delgado-Mora L., Noval S., Vallespín E.. Whole Exome Sequencing of 20 Spanish Families: Candidate Genes for Non-Syndromic Pediatric Cataracts. International Journal of Molecular Sciences. July 2023. DOI: 10.3390/ijms241411429.

Impacto: 4.9. Cuartil: Q1

Al-Akioui-Sanz K., Pascual-Miguel B., Díaz-Almirón M., Mestre-Durán C., Navarro-Zapata A., Clares-Villa L., Martín-Cortázar C., Vicario J.L., Moreno M.Á., Balas A., De Paz R., Minguillón J., Pérez-Martínez A., Ferreras C.. Donor selection for adoptive cell therapy with CD45RA− memory T cells for patients with coronavirus disease 2019, and dexamethasone and interleukin-15 effects on the phenotype, proliferation and interferon gamma release. Cytotherapy. March 2023. DOI: 10.1016/j.jcyt.2022.12.001.

Impacto: 3.7. Cuartil: Q1

Al-Akioui Sanz K., Echecopar Parente C., Ferreras C., Menéndez Ribes M., Navarro A., Mestre C., Clares L., Vicario J.L., Balas A., De Paz R., López Granados E., Sánchez Zapardiel E., Jiménez C., López-Oliva M., Ramos E., Hernández-Oliveros F., Pérez-Martínez A.. Familial CD45RA– T cells to treat severe refractory infections in immunocompromised patients. Frontiers in Medicine. 8 February 2023. DOI: 10.3389/fmed.2023.1083215.

Impacto: 3.1. Cuartil: Q1

Mestre-Durán C., Martín-Cortázar C., García-Solís B., Pernas A., Pertíñez L., Galán V., Sisinni L., Clares-Villa L., Navarro-Zapata A., Al-Akioui K., Escudero A., Ferreras C., Pérez-Martínez A.. Ruxolitinib does not completely abrogate the functional capabilities of TLR4/9 ligand-activated NK cells. Frontiers in Immunology. 5 January 2023. DOI: 10.3389/fimmu.2022.1045316.

Impacto: 5.7. Cuartil: Q1

Ibáñez-Navarro M., Fernández A., Escudero A., Esteso G., Campos-Silva C., Navarro-Aguadero M.Á., Leivas A., Caracuel B.R., Rodríguez-Antolín C., Ortiz A., Navarro-Zapata A., Mestre-Durán C., Izquierdo M., Balaguer-Pérez M., Ferreras C., Martínez-López J., Valés-Gómez M., Pérez-Martínez A., Fernández L.. NKG2D-CAR memory T cells target pediatric T-cell acute lymphoblastic leukemia in vitro and in vivo but fail to eliminate leukemia initiating cells. Frontiers in Immunology. 2023. DOI: 10.3389/fimmu.2023.1187665.

Impacto: 5.7. Cuartil: Q1

Arruti N., Rodríguez-Solana P., Nieves-Moreno M., Guerrero-Carretero M., del Pozo Á., Montaño V.E.F., Santos-Simarro F., Rikeros-Orozco E., Delgado-Mora L., Vallespín E., Noval S.. OPA1 Dominant Optic Atrophy: Diagnostic Approach in the Pediatric Population. Current Issues in Molecular Biology. January 2023. DOI: 10.3390/cimb45010030.

Impacto: 2.8. Cuartil: Q3

Gonzaga A., Andreu E., Hernández-Blasco L.M., Meseguer R., Al-Akioui-Sanz K., Soria-Juan B., Sanjuan-Gimenez J.C., Ferreras C., Tejedo J.R., Lopez-Lluch G., Goterris R., Maciá L., Sempere-Ortells J.M., Hmadcha A., Borobia A., Vicario J.L., Bonora A., Aguilar-Gallardo C., Poveda J.L., Arbona C., Alenda C., Tarín F., Marco F.M., Merino E., Jaime F., Ferreres J., Figueira J.C., Cañada-Illana C., Querol S., Guerreiro M., Eguizabal C., Martín-Quirós A., Robles-Marhuenda Á., Pérez-Martínez A., Solano C., Soria B.. Rationale for combined therapies in severe-to-critical COVID-19 patients. Frontiers in Immunology. 2023. DOI: 10.3389/fimmu.2023.1232472.

Impacto: 5.7. Cuartil: Q1

Fernández-Gutiérrez E., Fernández-Pérez P., Boto-De-Los-Bueis A., García-Fernández L., Rodríguez-Solana P., Solís M., Vallespín E.. Posterior Polymorphous Corneal Dystrophy in a Patient with a Novel ZEB1 Gene Mutation. International Journal of Molecular Sciences. January 2023. DOI: 10.3390/ijms24010209.

Impacto: 4.9. Cuartil: Q1

Morgan R.D., Ferreras C., Peset I., Avizienyte E., Renehan A.G., Edmondson R.J., Murphy A.D., Nicum S., Van Brussel T., Clamp A.R., Lambrechts D., Zhou C., Jayson G.C.. c-MET/VEGFR-2 co-localisation impacts on survival following bevacizumab therapy in epithelial ovarian cancer: an exploratory biomarker study of the phase 3 ICON7 trial. BMC Medicine. December 2022. DOI: 10.1186/s12916-022-02270-y.

Impacto: 9.3. Cuartil: Q1

Errazquin R., Page A., Suñol A., Segrelles C., Carrasco E., Peral J., Garrido-Aranda A., Del Marro S., Ortiz J., Lorz C., Minguillon J., Surralles J., Belendez C., Alvarez M., Balmaña J., Bravo A., Ramirez A., Garcia-Escudero R.. Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemia. Oral Oncology. November 2022. DOI: 10.1016/j.oraloncology.2022.106184.

Impacto: 4.8. Cuartil: Q1 (1er decil)

Casado J.A., Valeri A., Sanchez-Dominguez R., Vela P., Lopez A., Navarro S., Alberquilla O., Hanenberg H., Pujol R., Segovia J.C., Minguillon J., Surralles J., De Heredia C.D., Sevilla J., Rio P., Bueren J.A.. Upregulation of NKG2D ligands impairs hematopoietic stem cell function in Fanconi anemia. Journal of Clinical Investigation. 1 August 2022. DOI: 10.1172/JCI142842.

Impacto: 15.9. Cuartil: Q1 (1er decil)

Galán-Gómez V., Matamala N., Ruz-Caracuel B., Valle-Simón P., Ochoa-Fernández B., Guerra-García P., Pernas-Sánchez A., Minguillón J., González B., Martínez-Romera I., San Román-Pacheco S., Estival-Monteliú P., Ibáñez-Navarro A., Pérez-Martínez A., Escudero-López A.. Advanced Molecular Characterisation in Relapsed and Refractory Paediatric Acute Leukaemia, the Key for Personalised Medicine. Journal of Personalized Medicine. June 2022. DOI: 10.3390/jpm12060881.

Impacto: 3.4. Cuartil: Q2

Luque J., Mendes I., Gómez B., Morte B., López de Heredia M., Herreras E., Corrochano V., Bueren J., Gallano P., Artuch R., Fillat C., Pérez-Jurado L.A., Montoliu L., Carracedo Á., Millán J.M., Webb S.M., Palau F., Aguado C., Aguado C., Aguilera P., Albiñana V., Alías L., Almoguera B., Alonso J., Alonso-Ferreira V., Alvarez-Mora M.I., Antiñolo G., Arbones M.L., Arenas J., Arjona E., Armangue T., Armstrong J., Arnedo M., Masó A.A., Avila-Fernandez A., Ayuso C., Badell I., Badenas C., Baeza M.L., Baiget M., Balcells S., Ballesta-Martínez M.J., Barahona M.J., Barros F., Bartoccioni P.C., Pilar Bayona-Bafaluy M., Benito Sanz S., Bernabéu C., Bernal S., Blanco-Kelly F., Blázquez A., Bodoy S., Bogliolo M., Borralleras C., Borrego S., Botella L.M., Bou de Pieri F., Bovolenta P., Bravo-Gil N., Brea A., Bueno-Lozano G., Bueren J., Bustamante A., Caballero T., Camacho-Macorra C., Cámara Y., Camats-Tarruella N., Campos Barros Á., Campuzano V., Cantarero L., Cantó J., Caparrós-Martín J., Cardellach F., Carmona R., Carrera C., Carretero M., Casado M., Casado J., Casasnovas C., Cascón A., Casino P., Castaño L., Castilla-Vallmanya L., Catala A., Luisa Cayuela M., Cediel R., Cervera J., Codina-Solà M., Contreras J., Cormand B., Corominas R., Corral J., Cortés-Rodríguez A., Corton M., Costa-Roger M., Cozar M., Crespo I., Crispi F.. CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative. Clinical Genetics. 01 May-June 2022. DOI: 10.1111/cge.14113.

Impacto: 3.5. Cuartil: Q2

Escudero A., Ferreras C., Rodriguez-Salas N., Corral D., Rodriguez L., Pérez-Martínez A.. Cancer predisposing syndrome: a retrospective cohort analysis in a pediatric and multidisciplinary genetic cancer counseling unit. International Journal of Clinical Oncology. May 2022. DOI: 10.1007/s10147-022-02133-9.

Impacto: 3.3. Cuartil: Q3

González-Iglesias E., López-Vázquez A., Noval S., Nieves-Moreno M., Granados-Fernández M., Arruti N., Rosa-Pérez I., Pacio-Míguez M., Montaño V.E.F., Rodríguez-Solana P., Del Pozo A., Santos-Simarro F., Vallespín E.. Next-Generation Sequencing Screening of 43 Families with Non-Syndromic Early-Onset High Myopia: A Clinical and Genetic Study. International Journal of Molecular Sciences. April-2 2022. DOI: 10.3390/ijms23084233.

Impacto: 5.6. Cuartil: Q1

Herrera L., Martin-Inaraja M., Santos S., Inglés-Ferrándiz M., Azkarate A., Perez-Vaquero M.A., Vesga M.A., Vicario J.L., Soria B., Solano C., De Paz R., Marcos A., Ferreras C., Perez-Martinez A., Eguizabal C.. Identifying SARS-CoV-2 ‘memory’ NK cells from COVID-19 convalescent donors for adoptive cell therapy. Immunology. February 2022. DOI: 10.1111/imm.13432.

Impacto: 6.4. Cuartil: Q2

Fernández A., Pérez-Martínez A., Escudero A., Mirones I., González B., de Paz R., Matamala N., Clares L., Navarro A., Galán V., Martínez-Romera I., Martínez-López J., Leivas A., Valés-Gómez M., Ferreras C., Fernández L.. Infusion of haploidentical NKG2D-CAR-T<inf>CD45RA-</inf> cells in two pediatric patients with advanced relapsed and refractory acute leukemia was safe but achieved no clinical benefits. Leukemia and Lymphoma. 2022. DOI: 10.1080/10428194.2022.2057490.

Impacto: 2.6. Cuartil: Q3

Minguillón J., Ramírez M.J., Rovirosa L., Bustamante-Madrid P., Camps-Fajol C., De Garibay G.R., Shimelis H., Montanuy H., Pujol R., Hernandez G., Bogliolo M., Castillo P., Soucy P., Martrat G., Gómez A., Cuadras D., García M.J., Gayarre J., Lázaro C., Benítez J., Couch F.J., Angel Pujana M., Surrallés J.. CDK5RAP3, a New BRCA2 Partner That Regulates DNA Repair, Is Associated with Breast Cancer Survival. Cancers. January-2 2022. DOI: 10.3390/cancers14020353.

Impacto: 5.2. Cuartil: Q2

Encarnación J.A., Cerezuela P., Español I., García M.R., Manso C., De la Fuente I., Garrigós N., Viney A., Minguillon J., Surrallés J.. Fanconi-like anemia related to a FANCM mutation. European Journal of Medical Genetics. January 2022. DOI: 10.1016/j.ejmg.2021.104399.

Impacto: 1.9. Cuartil: Q4

García-García I., Guerra-García P., Ferreras C., Borobia A.M., Carcas A.J., Queiruga-Parada J., Vicario J.L., Mirones I., Solano C., Eguizabal C., Soria B., Pérez-Martínez A.. A phase I/II dose-escalation multi-center study to evaluate the safety of infusion of natural killer cells or memory T cells as adoptive therapy in coronavirus pneumonia and/or lymphopenia: RELEASE study protocol. Trials. December 2021. DOI: 10.1186/s13063-021-05625-7.

Impacto: 2.728. Cuartil: Q4

Aguirre-Portoles C., Payne R., Trautz A., Foskett J.K., Natale C.A., Seykora J.T., Ridky T.W.. ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma. Cancer Research. 1 December 2021. DOI: 10.1158/0008-5472.CAN-21-0982.

Impacto: 13.312. Cuartil: Q1 (1er decil)

Ferreras C., Fernández L., Clares-Villa L., Ibáñez-Navarro M., Martín-Cortázar C., Esteban-Rodríguez I., Saceda J., Pérez-Martínez A.. Facing car t cell challenges on the deadliest paediatric brain tumours. Cells. November 2021. DOI: 10.3390/cells10112940.

Impacto: 7.666. Cuartil: Q2

Pérez-Martínez A., Mora-Rillo M., Ferreras C., Guerra-García P., Pascual-Miguel B., Mestre-Durán C., Borobia A.M., Carcas A.J., Queiruga-Parada J., García I., Sánchez-Zapardiel E., Gasior M., De Paz R., Marcos A., Vicario J.L., Balas A., Moreno M.A., Eguizabal C., Solano C., Arribas J.R., Buckley R.d.M., Montejano R., Soria B.. Phase I dose-escalation single centre clinical trial to evaluate the safety of infusion of memory T cells as adoptive therapy in COVID-19 (RELEASE). EClinicalMedicine. September 2021. DOI: 10.1016/j.eclinm.2021.101086.

Impacto: 17.033. Cuartil: Q1 (1er decil)

Ramírez M.J., Pujol R., Trujillo-Quintero J.P., Minguillón J., Bogliolo M., Río P., Navarro S., Casado J.A., Badell I., Carrasco E., Balmaña J., Català A., Sevilla J., Beléndez C., Argilés B., López M., Díaz de Heredia C., Rao G., Nicoletti E., Schwartz J.D., Bueren J.A., Surrallés J.. Natural gene therapy by reverse mosaicism leads to improved hematology in Fanconi anemia patients. American Journal of Hematology. 1 August 2021. DOI: 10.1002/ajh.26234.

Impacto: 13.265. Cuartil: Q1 (1er decil)

Martínez-Rubio Á., Chulián S., Goñi C.B., Orellana M.R., Martínez A.P., Navarro-Zapata A., Ferreras C., Pérez-García V.M., Rosa M.. A mathematical description of the bone marrow dynamics during car T-cell therapy in B-cell childhood acute lymphoblastic leukemia. International Journal of Molecular Sciences. 2 June 2021. DOI: 10.3390/ijms22126371.

Impacto: 6.208. Cuartil: Q1

Gasior M., Ferreras C., de Paz R., Bueno D., Mozo Y., Sisinni L., Canizales J.T., González B., Olivas-Mazón R., Marcos A., Romero A.B., Constanzo A., Mirones I., Fernández-Arroyo A., Balas A., Vicario J.L., Escudero A., Yuste V.J., Pérez-Martínez A.. The role of early natural killer cell adoptive infusion before engraftment in protecting against human herpesvirus-6B encephalitis after naïve T-cell-depleted allogeneic stem cell transplantation. Transfusion. May 2021. DOI: 10.1111/trf.16354.

Impacto: 3.337. Cuartil: Q3

Gómez García L.M., Escudero A., Mestre C., Fuster Soler J.L., Martínez A.P., Vagace Valero J.M., Vela M., Ruz B., Navarro A., Fernández L., Fernández A., Leivas A., Martínez-López J., Ferreras C., De Paz R., Blanquer M., Galán V., González B., Corral D., Sisinni L., Mirones I., Balas A., Vicario J.L., Valle P., Borobia A.M., Pérez-Martínez A.. Phase 2 Clinical Trial of Infusing Haploidentical K562-mb15-41BBL–Activated and Expanded Natural Killer Cells as Consolidation Therapy for Pediatric Acute Myeloblastic Leukemia. Clinical Lymphoma, Myeloma and Leukemia. May 2021. DOI: 10.1016/j.clml.2021.01.013.

Impacto: 2.822. Cuartil: Q3

Ferreras C., Pascual-Miguel B., Mestre-Durán C., Navarro-Zapata A., Clares-Villa L., Martín-Cortázar C., De Paz R., Marcos A., Vicario J.L., Balas A., García-Sánchez F., Eguizabal C., Solano C., Mora-Rillo M., Soria B., Pérez-Martínez A.. SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy. Frontiers in Cell and Developmental Biology. 25 February 2021. DOI: 10.3389/fcell.2021.620730.

Impacto: 6.081. Cuartil: Q1

Fernández A., Navarro‐zapata A., Escudero A., Matamala N., Ruz‐caracuel B., Mirones I., Pernas A., Cobo M., Casado G., Lanzarot D., Rodríguez‐antolín C., Vela M., Ferreras C., Mestre C., Viejo A., Leivas A., Martínez J., Fernández L., Pérez‐martínez A.. Optimizing the procedure to manufacture clinical‐grade NK cells for adoptive immunotherapy. Cancers. 1 February 2021. DOI: 10.3390/cancers13030577.

Impacto: 6.575. Cuartil: Q1

Torres Canizales J., Ferreras C., Pascual A., Alonso L., Regueiro A., Plaza M., Pérez Hurtado J.M., Benito A., Couselo J.M., Fuster J.L., Díaz-Almirón M., Bueno D., Mozo Y., Gómez López A., Vicario J.L., Balas A., Sisinni L., Díaz de Heredia C., Pérez-Martínez A.. Haploidentical transplantation in pediatric non-malignant diseases: A retrospective analysis on behalf of the Spanish Group for Hematopoietic Transplantation (GETH). European Journal of Haematology. February 2021. DOI: 10.1111/ejh.13536.

Impacto: 3.674. Cuartil: Q3

Mozo Y., Bueno D., Sisinni L., Fernández-Arroyo A., Rosich B., Martínez A.P., Benítez-Carabante M.I., Alonso L., Uría M.L., Heredia C.D.d., Mestre-Duran C., Pascual C.F.B., Torres J., Losantos I., Escudero A., Ruz-Caracuel B.. Ruxolitinib for steroid-refractory graft versus host disease in pediatric HSCT: high response rate and manageable toxicity. Pediatric Hematology and Oncology. 2021. DOI: 10.1080/08880018.2020.1868637.

Impacto: 2.07. Cuartil: Q3

Riera P., Rodríguez-Santiago B., Lasa A., Gonzalez-Quereda L., Martín B., Salazar J., Sebio A., Virgili A.C., Minguillón J., Camps C., Surrallés J., Páez D.. Novel somatic genetic variants as predictors of resistance to egfr-targeted therapies in metastatic colorectal cancer patients. Cancers. August 2020. DOI: 10.3390/cancers12082245.

Impacto: 6.639. Cuartil: Q1

Montanuy H., Camps-Fajol C., Carreras-Puigvert J., Häggblad M., Lundgren B., Aza-Carmona M., Helleday T., Minguillón J., Surrallés J.. High content drug screening for Fanconi anemia therapeutics. Orphanet Journal of Rare Diseases. 30 June 2020. DOI: 10.1186/s13023-020-01437-1.

Impacto: 4.123. Cuartil: Q2

Montanuy H., Martínez-Barriocanal A., Casado J.A., Rovirosa L., Ramírez M.J., Nieto R., Carrascoso-Rubio C., Riera P., Gonzalez A., Lerma E., Lasa A., Carreras-Puigvert J., Helleday T., Bueren J.A., Arango D., Minguillon J., Surralles J.. Geﬁtinib and afatinib show potential efﬁcacy for fanconi anemia-related head and neck cancer. Clinical Cancer Research. 15 June 2020. DOI: 10.1158/1078-0432.CCR-19-1625.

Impacto: 12.531. Cuartil: Q1 (1er decil)

Ramírez M.J., Minguillón J., Loveless S., Lake K., Carrasco E., Stjepanovic N., Balmaña J., Català A., Mehta P.A., Surrallés J.. Chromosome fragility in the buccal epithelium in patients with Fanconi anemia. Cancer Letters. 1 March 2020. DOI: 10.1016/j.canlet.2019.12.008.

Impacto: 8.679. Cuartil: Q1

Jara P., Baker A., Baumann U., Borobia A.M., Branchereu S., Candusso M., Carcas A.J., Chardot C., Cobas J., D'Antiga L., Ferreras C., Fitzpatrick E., Frauca E., Hernández-Oliveros F., Kaliciński P., Lindemans C., Lopes M.F., López-Granados E., De Magnée C., Mota C., Muñoz J.M., Ojeda J.J., Pérez-Martínez A., Perilongo G., Rascon J., Sciveres M., Stone R., Tarutis V., Toporski J., Torres J.M., Wennberg L.. Cross-cutting view of current challenges in paediatric solid organ and haematopoietic stem cell transplantation in Europe: The European Reference Network TransplantChild. Orphanet Journal of Rare Diseases. 15 January 2020. DOI: 10.1186/s13023-020-1293-0.

Impacto: 4.123. Cuartil: Q2

Pérez-Martínez A., Ferreras C., Pascual A., Gonzalez-Vicent M., Alonso L., Badell I., Fernández Navarro J.M., Regueiro A., Plaza M., Pérez Hurtado J.M., Benito A., Beléndez C., Couselo J.M., Fuster J.L., Díaz-Almirón M., Bueno D., Mozo Y., Marsal J., Gómez López A., Sisinni L., de Heredia C.D., Díaz M.Á.. Haploidentical transplantation in high-risk pediatric leukemia: A retrospective comparative analysis on behalf of the Spanish working Group for bone marrow transplantation in children (GETMON) and the Spanish Grupo for hematopoietic transplantation (GETH). American Journal of Hematology. 1 January 2020. DOI: 10.1002/ajh.25661.

Impacto: 10.047. Cuartil: Q1 (1er decil)

Vela M., Bueno D., González-Navarro P., Brito A., Fernández L., Escudero A., Valentín J., Mestre-Durán C., Arranz-álvarez M., de Diego R.P., Mendiola M., Pozo-Kreilinger J.J., Pérez-Martínez A.. Anti-CXCR4 antibody combined with activated and expanded natural killer cells for sarcoma immunotherapy. Frontiers in Immunology. 2019. DOI: 10.3389/fimmu.2019.01814.

Impacto: 5.085. Cuartil: Q1

Minguillón J., Surrallés J.. Therapeutic research in the crystal chromosome disease Fanconi anemia. Mutation Research - Genetic Toxicology and Environmental Mutagenesis. December 2018. DOI: 10.1016/j.mrgentox.2018.05.012.

Impacto: 2.256. Cuartil: Q3

Hernández G., Ramírez M.J., Minguillón J., Quiles P., Ruiz De Garibay G., Aza-Carmona M., Bogliolo M., Pujol R., Prados-Carvajal R., Fernández J., García N., López A., Gutiérrez-Enríquez S., Diez O., Benítez J., Salinas M., Teulé A., Brunet J., Radice P., Peterlongo P., Schindler D., Huertas P., Puente X.S., Lázaro C., Pujana M.À., Surrallés J.. Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. Nature Communications. 1 December 2018. DOI: 10.1038/s41467-018-03433-3.

Impacto: 11.878. Cuartil: Q1 (1er decil)

Aguirre-Portolés C., Feliu J., Reglero G., Ramírez de Molina A.. ABCA1 overexpression worsens colorectal cancer prognosis by facilitating tumour growth and caveolin-1-dependent invasiveness, and these effects can be ameliorated using the BET inhibitor apabetalone. Molecular Oncology. October 2018. DOI: 10.1002/1878-0261.12367.

Impacto: 5.962. Cuartil: Q1

Aguirre-Portolés C., Fernández L.P., De Molina A.R.. Precision nutrition for targeting lipid metabolism in colorectal cancer. Nutrients. October 2017. DOI: 10.3390/nu9101076.

Impacto: 4.196. Cuartil: Q1

Belo H., Silva G., Cardoso B.A., Porto B., Minguillon J., Barbot J., Coutinho J., Casado J.A., Benedito M., Saturnino H., Costa E., Bueren J.A., Surralles J., Almeida A.. Epigenetic Alterations in Fanconi anaemia: Role in pathophysiology and therapeutic potential. PLoS ONE. 14 October 2015. DOI: 10.1371/journal.pone.0139740.

Impacto: 3.057. Cuartil: Q1

Ferreras C., Cole C.L., Urban K., Jayson G.C., Avizienyte E.. Segregation of late outgrowth endothelial cells into functional endothelial CD34− and progenitor-like CD34+ cell populations. Angiogenesis. January 2015. DOI: 10.1007/s10456-014-9446-1.

Impacto: 4.301. Cuartil: Q1

De Castro I.P., Aguirre-Portolés C., Fernández-Miranda G., Cañamero M., Cowley D.O., Van Dyke T., Malumbres M.. Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Research. 15 November 2013. DOI: 10.1158/0008-5472.CAN-13-0586.

Impacto: 9.284. Cuartil: Q1 (1er decil)

Bogliolo M., Schuster B., Stoepker C., Derkunt B., Su Y., Raams A., Trujillo J.P., Minguillón J., Ramírez M.J., Pujol R., Casado J.A., Baños R., Rio P., Knies K., Zúñiga S., Benítez J., Bueren J.A., Jaspers N.G.J., Schärer O.D., De Winter J.P., Schindler D., Surrallés J.. Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia. American Journal of Human Genetics. 2 May 2013. DOI: 10.1016/j.ajhg.2013.04.002.

Impacto: 10.987. Cuartil: Q1 (1er decil)

Ferreras C., Rushton G., Cole C.L., Babur M., Telfer B.A., Van Kuppevelt T.H., Gardiner J.M., Williams K.J., Jayson G.C., Avizienyte E.. Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor. Journal of Biological Chemistry. 19 October 2012. DOI: 10.1074/jbc.M112.384875.

Impacto: 4.651. Cuartil: Q1

Aguirre-Portolés C., Bird A.W., Hyman A., Cañamero M., Pérez De Castro I., Malumbres M.. Tpx2 controls spindle integrity, genome stability, and tumor development. Cancer Research. 15 March 2012. DOI: 10.1158/0008-5472.CAN-11-1971.

Impacto: 8.65. Cuartil: Q1 (1er decil)

Buxadé M., Lunazzi G., Minguillón J., Iborra S., Berga-Bolaños R., del Val M., Aramburu J., López-Rodríguez C.. Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5. Journal of Experimental Medicine. February 2012. DOI: 10.1084/jem.20111569.

Impacto: 13.214. Cuartil: Q1 (1er decil)

de Castro I.P., Aguirre-Portolés C., Martin B., Fernández-Miranda G., Klotzbucher A., Kubbutat M.H.G., Megías D., Arlot-Bonnemains Y., Malumbres M.. A SUMOylation motif in Aurora-A: Implications for spindle dynamics and oncogenesis. Frontiers in Oncology. 2011. DOI: 10.3389/fonc.2011.00050.

Ferreras C., Lancrin C., Lie-A-Ling M., Kouskoff V., Lacaud G.. Identification and characterization of a novel transcriptional target of RUNX1/AML1 at the onset of hematopoietic development. Blood. 21 July 2011. DOI: 10.1182/blood-2010-06-294124.

Impacto: 9.898. Cuartil: Q1 (1er decil)

Arechaga I., Martínez-Costa O.H., Ferreras C., Carrascosa J.L., Aragón J.J.. Electron microscopy analysis of mammalian phosphofructokinase reveals an unusual 3-dimensional structure with significant implications for enzyme function. FASEB Journal. December 2010. DOI: 10.1096/fj.10-165845.

Impacto: 6.515. Cuartil: Q1 (1er decil)

Fernández-Miranda G., Pérez De Castro I., Carmena M., Aguirre-Portolés C., Ruchaud S., Fant X., Montoya G., Earnshaw W.C., Malumbres M.. SUMOylation modulates the function of Aurora-B kinase. Journal of Cell Science. 15 August 2010. DOI: 10.1242/jcs.065565.

Impacto: 6.29. Cuartil: Q1

Lancrin C., Sroczynska P., Serrano A.G., Gandillet A., Ferreras C., Kouskoff V., Lacaud G.. Blood cell generation from the hemangioblast. Journal of Molecular Medicine. February 2010. DOI: 10.1007/s00109-009-0554-0.

Impacto: 5.192. Cuartil: Q1

Ferreras C., Hernández E.D., Martínez-Costa O.H., Aragón J.J.. Subunit interactions and composition of the fructose 6-phosphate catalytic site and the fructose 2,6-bisphosphate allosteric site of mammalian phosphofructokinase. Journal of Biological Chemistry. 3 April 2009. DOI: 10.1074/jbc.M807737200.

Impacto: 5.328. Cuartil: Q1

Morancho B., Minguillón J., Molkentin J.D., López-Rodríguez C., Aramburu J.. Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice. BMC Molecular Biology. 25 January 2008. DOI: 10.1186/1471-2199-9-13.

Impacto: 2.81. Cuartil: Q2

Aramburu J., Drews-Elger K., Estrada-Gelonch A., Minguillón J., Morancho B., Santiago V., López-Rodríguez C.. Regulation of the hypertonic stress response and other cellular functions by the Rel-like transcription factor NFAT5. Biochemical Pharmacology. 30 November 2006. DOI: 10.1016/j.bcp.2006.07.002.

Impacto: 3.581. Cuartil: N/D

Minguillón J., Morancho B., Kim S.J., López-Botet M., Aramburu J.. Concentrations of cyclosporin A and FK506 that inhibit IL-2 induction in human T cells do not affect TGF-β1 biosynthesis, whereas higher doses of cyclosporin A trigger apoptosis and release of preformed TGF-β1. Journal of Leukocyte Biology. May 2005. DOI: 10.1189/jlb.0904503.

Impacto: 4.627. Cuartil: N/D