Investigadores
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Investigadores
Instituto de Investigación Hospital 12 de Octubre (i+12). UCM. Madrid.
Terapia de células somáticas y medicina regenerativa
Desarrollos Tecnológicos y Terapéuticos
Agustin G Zapata González
Investigador principal
Grupo de Investigación: Instituto de Investigación Hospital 12 de Octubre (i+12). UCM. Madrid.
Alberto Varas Fajardo
Investigador colaborador
Grupo de Investigación: Instituto de Investigación Hospital 12 de Octubre (i+12). UCM. Madrid.
Belén Blanco Durango
Investigador colaborador
Grupo de Investigación: Instituto de Investigación Hospital 12 de Octubre (i+12). UCM. Madrid.
David Alfaro Sánchez
Investigador colaborador
Grupo de Investigación: Instituto de Investigación Hospital 12 de Octubre (i+12). UCM. Madrid.
JARIS VALENCIA MAHÓN
Investigador colaborador
Grupo de Investigación: Instituto de Investigación Hospital 12 de Octubre (i+12). UCM. Madrid.
José Javier García-Ceca Hernández
Investigador colaborador
Grupo de Investigación: Instituto de Investigación Hospital 12 de Octubre (i+12). UCM. Madrid.
Lidia Martínez Fernández de Sevilla
Investigador colaborador
Grupo de Investigación: Instituto de Investigación Hospital 12 de Octubre (i+12). UCM. Madrid.
MARIA ANGELES VICENTE LÓPEZ
Investigador colaborador
Grupo de Investigación: Instituto de Investigación Hospital 12 de Octubre (i+12). UCM. Madrid.
Mariano Rubén Rodríguez Sosa
Investigador colaborador
Grupo de Investigación: Instituto de Investigación Hospital 12 de Octubre (i+12). UCM. Madrid.
Rosa Sacedón Ayuso
Investigador colaborador
Grupo de Investigación: Instituto de Investigación Hospital 12 de Octubre (i+12). UCM. Madrid.
Sara Montero Herradón
Investigador colaborador
Grupo de Investigación: Instituto de Investigación Hospital 12 de Octubre (i+12). UCM. Madrid.
Ortiz-Sánchez P., González-Soto S., Villamizar L.H., Valencia J., Jiménez E., Sacedón R., Ramírez M., Fariñas I., Varas A., Fernández-Sevilla L.M., Vicente Á.. Meningeal leukaemic aggregates as foci of cell expansion and chemoresistance in acute lymphoblastic leukaemia metastasis. Cellular Oncology. 2025. DOI: 10.1007/s13402-025-01043-y.
Impacto: 4.9. Cuartil: Q1
Montero-Herradón S., García-Ceca J., Villarejo-Torres M., Zapata A.G.. Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a model of collagen-induced arthritis. Cellular and Molecular Life Sciences. December 2024. DOI: 10.1007/s00018-024-05197-0.
Impacto: 6.2. Cuartil: Q1
Callejo M., Morales-Cano D., Olivencia M.A., Mondejar-Parreño G., Barreira B., Tura-Ceide O., Martínez V.G., Serrano-Navarro A., Moreno L., Morrell N., Perros F., Vicente A., Cogolludo A., Perez-Vizcaino F.. Vitamin D receptor and its antiproliferative effect in human pulmonary arterial hypertension. Scientific Reports. December 2024. DOI: 10.1038/s41598-024-78380-9.
Impacto: 3.8. Cuartil: Q1
Jiménez E., Vázquez A., González S., Sacedón R., Fernández-Sevilla L.M., Varas A., Subiza J.L., Valencia J., Vicente Á.. Mucosal Bacterial Immunotherapy Attenuates the Development of Experimental Colitis by Reducing Inflammation Through the Regulation of Myeloid Cells. International Journal of Molecular Sciences. December 2024. DOI: 10.3390/ijms252413629.
Impacto: 4.9. Cuartil: Q1
Quintana-Castanedo L., Sánchez-Ramón S., Maseda R., Illera N., Pérez-Conde I., Molero-Luis M., Butta N., Arias-Salgado E.G., Monzón-Manzano E., Zuluaga P., Martínez-Santamaría L., Fernández-Arquero M., Llames S.G., Meana Á., de Lucas R., del Río M., Vicente Á., Escámez M.J., Sacedón R.. Unveiling the value of C-reactive protein as a severity biomarker and the IL4/IL13 pathway as a therapeutic target in recessive dystrophic epidermolysis bullosa: A multiparametric cross-sectional study. Experimental Dermatology. August 2024. DOI: 10.1111/exd.15146.
Impacto: 3.5. Cuartil: Q1
Gil-Chinchilla J.I., Zapata A.G., Moraleda J.M., García-Bernal D.. Bioengineered Mesenchymal Stem/Stromal Cells in Anti-Cancer Therapy: Current Trends and Future Prospects. Biomolecules. July 2024. DOI: 10.3390/biom14070734.
Impacto: 4.8. Cuartil: Q1
Rodríguez-Sosa M.R., del Castillo L.M., Belarra A., Zapata A.G., Alfaro D.. The lack of EphB3 receptor prevents bone loss in mouse models of osteoporosis. Journal of Bone and Mineral Research. July 2024. DOI: 10.1093/jbmr/zjae075.
Impacto: 5.1. Cuartil: Q1
Díez-Alonso L., Falgas A., Arroyo-Ródenas J., Romencín P.A., Martínez A., Gómez-Rosel M., Blanco B., Jiménez-Reinoso A., Mayado A., Pérez-Pons A., Aguilar-Sopeña Ó., Ramírez-Fernández Á., Segura-Tudela A., Perez-Amill L., Tapia-Galisteo A., Domínguez-Alonso C., Rubio-Pérez L., Jara M., Solé F., Hangiu O., Almagro L., Albitre Á., Penela P., Sanz L., Anguita E., Valeri A., García-Ortiz A., Río P., Juan M., Martínez-López J., Roda-Navarro P., Martín-Antonio B., Orfao A., Menéndez P., Bueno C., Álvarez-Vallina L.. Engineered T cells secreting anti-BCMA T cell engagers control multiple myeloma and promote immune memory in vivo. Science Translational Medicine. 2024. DOI: 10.1126/scitranslmed.adg7962.
Impacto: 15.8. Cuartil: Q1
(1er decil)
Gil-Chinchilla J.I., Bueno C., Martínez C.M., Ferrández-Múrtula A., García-Hernández A.M., Blanquer M., Molina-Molina M., Zapata A.G., Sackstein R., Moraleda J.M., García-Bernal D.. Optimizing cryopreservation conditions for use of fucosylated human mesenchymal stromal cells in anti-inflammatory/immunomodulatory therapeutics. Frontiers in Immunology. 2024. DOI: 10.3389/fimmu.2024.1385691.
Impacto: 5.7. Cuartil: Q1
Zapata A.G.. The fish spleen. Fish and Shellfish Immunology. January 2024. DOI: 10.1016/j.fsi.2023.109280.
Impacto: 4.1. Cuartil: Q1
(1er decil)
Jiménez-Reinoso A., Molero-Abraham M., Cirauqui C., Blanco B., Garrido-Martin E.M., Nehme-Álvarez D., Domínguez-Alonso C., Ramírez-Fernández Á., Díez-Alonso L., Nuñez-Buiza Á., González-Murillo Á., Tobes R., Pareja E., Ramírez-Orellana M., Rodriguez-Peralto J.L., Ferrer I., Zugazagoitia J., Paz-Ares L., Álvarez-Vallina L.. CD4<sup>+</sup> tumor-infiltrating lymphocytes secreting T cell-engagers induce regression of autologous patient-derived non-small cell lung cancer xenografts. OncoImmunology. 2024. DOI: 10.1080/2162402X.2024.2392897.
Impacto: 6.5. Cuartil: Q1
Martín-Antonio B., Blanco B., González-Murillo Á., Hidalgo L., Minguillón J., Pérez-Chacón G., Fernández L., Bareke H., París-Muñoz A., Mañas A., Aguirre-Portolés C., Navarro-Zapata A., Mestre-Durán C., Ibáñez-Navarro M., Clares-Villa L., Naharro S., Perez-Martinez A., Aldea M., Gaibar M., Ruiz-Navarro J., Izquierdo M., Zapata J.M., Tarifa E.E., Serrano-López J., Llamas-Sillero P., Murillo Á.G., Sánchez E.G., Martínez J.G., Simón A.R.S., Herrero B., Aguilera G.G., Morera B.H., Orellana M.R., Blanco-Durango B., Jiménez-Reinoso A., Lázaro-Gorines R., Zagorac I., Galisteo A.T., Ramirez-Fernández Á., Díez-Alonso L., Dominguez-Alonso C., Erce-Llamazares A., Hangiu O., Pérez L.R., Rosel M.G., Tudela A.S., Arroyo-Ródena J., Álvarez-Vallina L., Milla M.Á.R., Rodríguez P.G., Crespo B.S., García-Castro J.. Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations. Frontiers in Immunology. 2024. DOI: 10.3389/fimmu.2024.1386856.
Impacto: 5.7. Cuartil: Q1
Sacedón R., de Arriba M.C., Martínez-Santamaría L., Maseda R., Herráiz-Gil S., Jiménez E., Rosales I., Quintana L., Illera N., García M., Butta N., Fernández-Bello I., Lwin S.M., Fernández-Arquero M., León C., McGrath J.A., Vicente M.Á., del Río M., de Lucas R., Sánchez-Ramón S., Escámez M.J.. Gluten-sensitive enteropathy in recessive dystrophic epidermolysis bullosa. British Journal of Dermatology. December 2023. DOI: 10.1093/bjd/ljad313.
Impacto: 11.0. Cuartil: Q1
(1er decil)
Sánchez-Guijo F., Avendaño-Solá C., Badimón L., Bueren J.A., Canals J.M., Delgadillo J., Delgado J., Eguizábal C., Fernández-Santos M.E., García-Olmo D., González-Aseguinolaza G., Juan M., Martín F., Mata R., Montserrat N., Pérez-Martínez A., Pérez-Simón J.A., Prósper F., Urbano-Ispizua Á., Zapata A.G., Sureda A., Moraleda J.M.. Role of Hospital Exemption in Europe: position paper from the Spanish Advanced Therapy Network (TERAV). Bone Marrow Transplantation. June 2023. DOI: 10.1038/s41409-023-01962-0.
Impacto: 4.5. Cuartil: Q1
Rubio-Pérez L., Lázaro-Gorines R., Harwood S.L., Compte M., Navarro R., Tapia-Galisteo A., Bonet J., Blanco B., Lykkemark S., Ramírez-Fernández Á., Ferreras-Gutiérrez M., Domínguez-Alonso C., Díez-Alonso L., Segura-Tudela A., Hangiu O., Erce-Llamazares A., Blanco F.J., Santos C., Rodríguez-Peralto J.L., Sanz L., Álvarez-Vallina L.. A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response. OncoImmunology. 2023. DOI: 10.1080/2162402X.2023.2205336.
Impacto: 6.5. Cuartil: Q1
García-Ceca J., Montero-Herradón S., González A., Plaza R., Zapata A.G.. Altered thymocyte development observed in EphA4-deficient mice courses with changes in both thymic epithelial and extracellular matrix organization. Cellular and Molecular Life Sciences. November 2022. DOI: 10.1007/s00018-022-04610-w.
Impacto: 8.0. Cuartil: Q1
Hangiu O., Compte M., Dinesen A., Navarro R., Tapia-Galisteo A., Mandrup O.A., Erce-Llamazares A., Lázaro-Gorines R., Nehme-Álvarez D., Domínguez-Alonso C., Harwood S.L., Alfonso C., Blanco B., Rubio-Pérez L., Jiménez-Reinoso A., Díez-Alonso L., Blanco F.J., Sanz L., Howard K.A., Álvarez-Vallina L.. Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity. iScience. 16 September 2022. DOI: 10.1016/j.isci.2022.104958.
Impacto: 5.8. Cuartil: Q1
Olivencia M.A., Esquivel-Ruiz S., Callejo M., Mondéjar-Parreño G., Quintana-Villamandos B., Barreira B., Sacedón R., Cogolludo Á., Perros F., Mendes-Ferreira P., Pérez Vizcaíno F.. Cardiac and Pulmonary Vascular Dysfunction in Vitamin D–Deficient Bmpr2-Mutant Rats. American Journal of Respiratory Cell and Molecular Biology. September 2022. DOI: 10.1165/rcmb.2022-0001LE.
Impacto: 6.4. Cuartil: Q1
Sevilla-Movilla S., Fuentes P., Rodríguez-García Y., Arellano-Sánchez N., Krenn P.W., de Val S.I., Montero-Herradón S., García-Ceca J., Burdiel-Herencia V., Gardeta S.R., Aguilera-Montilla N., Barrio-Alonso C., Crainiciuc G., Bouvard D., García-Pardo A., Zapata A.G., Hidalgo A., Fässler R., Carrasco Y.R., Toribio M.L., Teixidó J.. ICAP-1 loss impairs CD8<sup>+</sup> thymocyte development and leads to reduced marginal zone B cells in mice. European Journal of Immunology. August 2022. DOI: 10.1002/eji.202149560.
Impacto: 5.4. Cuartil: Q2
Villagrasa A., Posada-González M., García-Arranz M., Zapata A.G., Vorwald P., Olmedillas-López S., Vega-Clemente L., García-Olmo D.. Implication of stem cells from adipose tissue in wound healing in obese and cancer patients. Cirugia y Cirujanos (English Edition). July 2022. DOI: 10.24875/CIRU.21000110.
Impacto: 0.5. Cuartil: Q4
Fernández-Santos M.E., Garcia-Arranz M., Andreu E.J., García-Hernández A.M., López-Parra M., Villarón E., Sepúlveda P., Fernández-Avilés F., García-Olmo D., Prosper F., Sánchez-Guijo F., Moraleda J.M., Zapata A.G.. Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome. Frontiers in Immunology. 9 June 2022. DOI: 10.3389/fimmu.2022.918565.
Impacto: 7.3. Cuartil: Q1
Fernández-Sevilla L.M., Valencia J., Ortiz-Sánchez P., Fraile-Ramos A., Zuluaga P., Jiménez E., Sacedón R., Martínez-Sánchez M.V., Jazbec J., Debeljak M., Fedders B., Stanulla M., Schewe D., Cario G., Minguela A., Ramírez M., Varas A., Vicente Á.. High BMP4 expression in low/intermediate risk BCP-ALL identifies children with poor outcomes. Blood. 2 June 2022. DOI: 10.1182/blood.2021013506.
Impacto: 20.3. Cuartil: Q1
(1er decil)
Zapata A.G.. Lympho-Hematopoietic Microenvironments and Fish Immune System. Biology. May 2022. DOI: 10.3390/biology11050747.
Blanco B., Ramírez-Fernández Á., Bueno C., Argemí-Muntadas L., Fuentes P., Aguilar-Sopeña Ó., Gutierrez-Agüera F., Zanetti S.R., Tapia-Galisteo A., Díez-Alonso L., Segura-Tudela A., Castellá M., Marzal B., Betriu S., Harwood S.L., Compte M., Lykkemark S., Erce-Llamazares A., Rubio-Pérez L., Jiménez-Reinoso A., Domínguez-Alonso C., Neves M., Morales P., Paz-Artal E., Guedan S., Sanz L., Toribio M.L., Roda-Navarro P., Juan M., Menéndez P., Álvarez-Vallina L.. Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers. Cancer Immunology Research. April 2022. DOI: 10.1158/2326-6066.CIR-21-0853.
Impacto: 10.1. Cuartil: Q1
Fernández-Sevilla L.M., Belenguer G., Martí-Prado B., Ortiz-Sánchez P., Ramírez M., Varas A., Fariñas I., Vicente Á.. Acute lymphoblastic leukemia cells are able to infiltrate the brain subventricular zone stem cell niche and impair neurogenesis. Haematologica. April 2022. DOI: 10.3324/haematol.2021.279383.
Impacto: 10.1. Cuartil: Q1
(1er decil)
Marins-Dos-Santos A., Ayres-Silva J.d.P., Antunes D., Moreira C.J.d.C., Pelajo-Machado M., Alfaro D., Zapata A.G., Bonomo A.C., Savino W., de Meis J., Farias-de-Oliveira D.A.. Oral Trypanosoma cruzi Acute Infection in Mice Targets Primary Lymphoid Organs and Triggers Extramedullary Hematopoiesis. Frontiers in Cellular and Infection Microbiology. 24 March 2022. DOI: 10.3389/fcimb.2022.800395.
Impacto: 5.7. Cuartil: Q1
Ramírez-Fernández Á., Aguilar-Sopeña Ó., Díez-Alonso L., Segura-Tudela A., Domínguez-Alonso C., Roda-Navarro P., Álvarez-Vallina L., Blanco B.. Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies. OncoImmunology. 2022. DOI: 10.1080/2162402X.2022.2054106.
Impacto: 7.2. Cuartil: Q1
Blanco B., Domínguez-Alonso C., Alvarez-Vallina L.. Bispecific Immunomodulatory Antibodies for Cancer Immunotherapy. Clinical Cancer Research. 15 October 2021. DOI: 10.1158/1078-0432.CCR-20-3770.
Impacto: 13.801. Cuartil: Q1
(1er decil)
Gómez-Ferrer M., Amaro-Prellezo E., Dorronsoro A., Sánchez-Sánchez R., Vicente Á., Cosín-Roger J., Barrachina M.D., Baquero M.C., Valencia J., Sepúlveda P.. Hif-overexpression and pro-inflammatory priming in human mesenchymal stromal cells improves the healing properties of extracellular vesicles in experimental crohn’s disease. International Journal of Molecular Sciences. October-2 2021. DOI: 10.3390/ijms222011269.
Impacto: 6.208. Cuartil: Q1
Montero-Herradón S., Zapata A.G.. Delayed maturation of thymic epithelium in mice with specific deletion of β-catenin gene in FoxN1 positive cells. Histochemistry and Cell Biology. October 2021. DOI: 10.1007/s00418-021-02012-w.
Impacto: 2.531. Cuartil: Q2
Compte M., Harwood S.L., Erce-Llamazares A., Tapia-Galisteo A., Romero E., Ferrer I., Garrido-Martin E.M., Enguita A.B., Ochoa M.C., Blanco B., Oteo M., Merino N., Nehme-Alvarez D., Hangiu O., Domínguez-Alonso C., Zonca M., Ramírez-Fernandez A., Blanco F.J., Morcillo M.A., Muñoz I.G., Melero I., Rodriguez-Peralto J.L., Paz-Ares L., Sanz L., Alvarez-Vallina L.. An Fc-free EGFR-specific 4-1BB-agonistic trimerbody displays broad antitumor activity in humanized murine cancer models without toxicity. Clinical Cancer Research. 1 June 2021. DOI: 10.1158/1078-0432.CCR-20-4625.
Impacto: 13.801. Cuartil: Q1
(1er decil)
Fañanas-Baquero S., Orman I., Aparicio F.B., de Miguel S.B., Merino J.G., Yañez R., Sainz Y.F., Sánchez R., Dessy-Rodríguez M., Alberquilla O., Alfaro D., Zapata A., Bueren J.A., Segovia J.C., Quintana-Bustamante O.. Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice. Haematologica. June 2021. DOI: 10.3324/haematol.2019.233924.
Impacto: 11.047. Cuartil: Q1
(1er decil)
García-Bernal D., García-Arranz M., Yáñez R.M., Hervás-Salcedo R., Cortés A., Fernández-García M., Hernando-Rodríguez M., Quintana-Bustamante Ó., Bueren J.A., García-Olmo D., Moraleda J.M., Segovia J.C., Zapata A.G.. The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy. Frontiers in Cell and Developmental Biology. 16 March 2021. DOI: 10.3389/fcell.2021.650664.
Impacto: 6.081. Cuartil: Q1
Montero-Herradón S., García-Ceca J., Zapata A.G.. How Many Thymic Epithelial Cells Are Necessary for a Proper Maturation of Thymocytes?. Frontiers in Immunology. 8 March 2021. DOI: 10.3389/fimmu.2021.618216.
Impacto: 8.786. Cuartil: Q1
García-Bernal D., García-Arranz M., García-Guillén A.I., García-Hernández A.M., Blanquer M., García-Olmo D., Sackstein R., Moraleda J.M., Zapata A.G.. Exofucosylation of Adipose Mesenchymal Stromal Cells Alters Their Secretome Profile. Frontiers in Cell and Developmental Biology. 26 November 2020. DOI: 10.3389/fcell.2020.584074.
Impacto: 6.684. Cuartil: Q1
Maseda R., Martínez-Santamaría L., Sacedón R., Butta N., Arriba M.d.C.d., García-Barcenilla S., García M., Illera N., Pérez-Conde I., Carretero M., Jiménez E., Melen G., Borobia A.M., Jiménez-Yuste V., Vicente Á., del Río M., de Lucas R., Escámez M.J.. Beneficial Effect of Systemic Allogeneic Adipose Derived Mesenchymal Cells on the Clinical, Inflammatory and Immunologic Status of a Patient With Recessive Dystrophic Epidermolysis Bullosa: A Case Report. Frontiers in Medicine. 26 November 2020. DOI: 10.3389/fmed.2020.576558.
Vázquez A., Fernández-Sevilla L.M., Jiménez E., Pérez-Cabrera D., Yañez R., Subiza J.L., Varas A., Valencia J., Vicente A.. Involvement of Mesenchymal Stem Cells in Oral Mucosal Bacterial Immunotherapy. Frontiers in Immunology. 19 November 2020. DOI: 10.3389/fimmu.2020.567391.
Impacto: 7.561. Cuartil: Q1
Fernández-Sevilla L.M., Valencia J., Flores-Villalobos M.A., Gonzalez-Murillo Á., Sacedón R., Jiménez E., Ramírez M., Varas A., Vicente Á.. The choroid plexus stroma constitutes a sanctuary for paediatric B-cell precursor acute lymphoblastic leukaemia in the central nervous system. Journal of Pathology. 1 October 2020. DOI: 10.1002/path.5510.
Impacto: 7.996. Cuartil: Q1
(1er decil)
García-Ceca J., Montero-Herradón S., Zapata A.G.. Intrathymic selection and defects in the thymic epithelial cell development. Cells. October 2020. DOI: 10.3390/cells9102226.
Impacto: 6.6. Cuartil: Q2
García-Ceca J., Montero-Herradón S., Zapata A.G.. Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development. Developmental Dynamics. 1 October 2020. DOI: 10.1002/dvdy.212.
Impacto: 3.78. Cuartil: Q1
(1er decil)
Blanco B., Ramírez-Fernández A., Alvarez-Vallina L.. Engineering Immune Cells for in vivo Secretion of Tumor-Specific T Cell-Redirecting Bispecific Antibodies. Frontiers in Immunology. 13 August 2020. DOI: 10.3389/fimmu.2020.01792.
Impacto: 7.561. Cuartil: Q1
Sánchez-Guijo F., García-Arranz M., López-Parra M., Monedero P., Mata-Martínez C., Santos A., Sagredo V., Álvarez-Avello J.M., Guerrero J.E., Pérez-Calvo C., Sánchez-Hernández M.V., Del-Pozo J.L., Andreu E.J., Fernández-Santos M.E., Soria-Juan B., Hernández-Blasco L.M., Andreu E., Sempere J.M., Zapata A.G., Moraleda J.M., Soria B., Fernández-Avilés F., García-Olmo D., Prósper F.. Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept study. EClinicalMedicine. August 2020. DOI: 10.1016/j.eclinm.2020.100454.
Alfaro D., Rodríguez-sosa M.R., Zapata A.G.. Eph/ephrin signaling and biology of mesenchymal stromal/stem cells. Journal of Clinical Medicine. February 2020. DOI: 10.3390/jcm9020310.
Impacto: 4.241. Cuartil: Q1
Sánchez-Guijo F., García-Olmo D., Prósper F., Martínez S., Zapata A., Fernández-Avilés F., Toledo-Aral J.J., Torres M., Fariñas I., Badimón L., Labandeira-García J.L., García-Sancho J., Moraleda J.M.. Spanish Cell Therapy Network (TerCel): 15 years of successful collaborative translational research. Cytotherapy. January 2020. DOI: 10.1016/j.jcyt.2019.11.001.
Impacto: 5.414. Cuartil: Q1
Muñoz J., Tobajas E., Juara S., Montero S., Zapata A.. FoxN1 mediates thymic cortex–medulla differentiation through modifying a developmental pattern based on epithelial tubulogenesis. Histochemistry and Cell Biology. 1 December 2019. DOI: 10.1007/s00418-019-01818-z.
Impacto: 3.418. Cuartil: Q1
(1er decil)
Valencia J., Fernández-Sevilla L.M., Fraile-Ramos A., Sacedón R., Jiménez E., Vicente A., Varas A.. Acute lymphoblastic leukaemia cells impair dendritic cell and macrophage differentiation: Role of bmp4. Cells. July 2019. DOI: 10.3390/cells8070722.
Impacto: 4.366. Cuartil: Q2
Muñoz J.J., Zapata A.G.. Thymus ontogeny and development. Thymus Transcriptome and Cell Biology. 11 April 2019. DOI: 10.1007/978-3-030-12040-5_2.
Blanco B., Compte M., Lykkemark S., Sanz L., Alvarez-Vallina L.. T Cell-Redirecting Strategies to 'sTAb’ Tumors: Beyond CARs and Bispecific Antibodies. Trends in Immunology. March 2019. DOI: 10.1016/j.it.2019.01.008.
Impacto: 13.422. Cuartil: Q1
(1er decil)
Alfaro D., Zapata A.. Eph/Ephrin-mediated stimulation of human bone marrow mesenchymal stromal cells correlates with changes in cell adherence and increased cell death. Stem Cell Research and Therapy. 26 June 2018. DOI: 10.1186/s13287-018-0912-3.
Impacto: 4.627. Cuartil: Q1
Montero-Herradón S., García-Ceca J., Zapata A.. Altered maturation of medullary TEC in EphB-deficient Thymi is recovered by RANK signaling stimulation. Frontiers in Immunology. 9 May 2018. DOI: 10.3389/fimmu.2018.01020.
Impacto: 4.716. Cuartil: Q2
Muñoz J., García-Ceca J., Montero-Herradón S., del Collado B., Alfaro D., Zapata A.. Can a proper T-cell development occur in an altered thymic epithelium? Lessons from EphB-deficient thymi. Frontiers in Endocrinology. 3 April 2018. DOI: 10.3389/fendo.2018.00135.
Impacto: 3.634. Cuartil: Q2
Martínez V.G., Rubio C., Martínez-Fernández M., Segovia C., López-Calderón F., Garín M.I., Teijeira A., Munera-Maravilla E., Varas A., Sacedón R., Guerrero F., Villacampa F., De La Rosa F., Castellano D., López-Collazo E., Paramio J.M., Vicente Á., Dueñas M.. BMP4 induces M2 macrophage polarization and favors tumor progression in bladder cancer. Clinical Cancer Research. 1 December 2017. DOI: 10.1158/1078-0432.CCR-17-1004.
Impacto: 10.199. Cuartil: Q1
(1er decil)
Montero-Herradón S., García-Ceca J., Zapata A.. EphB receptors, mainly EphB3, contribute to the proper development of cortical thymic epithelial cells. Organogenesis. 2 October 2017. DOI: 10.1080/15476278.2017.1389368.
Impacto: 2.567. Cuartil: Q2
García-Ceca J., Montero-Herradón S., Alfaro D., Zapata A.. Increased epithelial-free areas in thymuses with altered EphB-mediated thymocyte–thymic epithelial cell interactions. Histochemistry and Cell Biology. 1 October 2017. DOI: 10.1007/s00418-017-1583-3.
Impacto: 2.164. Cuartil: Q1
Martinez V.G., Ontoria-Oviedo I., Ricardo C.P., Harding S.E., Sacedon R., Varas A., Zapata A., Sepulveda P., Vicente A.. Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells. Stem Cell Research and Therapy. 29 September 2017. DOI: 10.1186/s13287-017-0659-2.
Impacto: 4.963. Cuartil: Q1
Valencia J., Jiménez E., Martínez V., Del Amo B., Hidalgo L., Entrena A., Fernández-Sevilla L., Del Río F., Varas A., Vicente Á., Sacedón R.. Characterization of human fibroblastic reticular cells as potential immunotherapeutic tools. Cytotherapy. 1 May 2017. DOI: 10.1016/j.jcyt.2017.01.010.
Impacto: 3.993. Cuartil: Q1
Blanco B., Herrero-Sánchez M.d.C., Rodríguez-Serrano C., García-Martínez M.L., Blanco J.F., Muntión S., García-Arranz M., Sánchez-Guijo F., del Cañizo C.. Immunomodulatory effects of bone marrow versus adipose tissue-derived mesenchymal stromal cells on NK cells: implications in the transplantation setting. European Journal of Haematology. 1 December 2016. DOI: 10.1111/ejh.12765.
Impacto: 2.653. Cuartil: Q2
Herrero-Sánchez M.C., Rodríguez-Serrano C., Almeida J., San Segundo L., Inogés S., Santos-Briz Á., García-Briñón J., Corchete L.A., San Miguel J.F., Del Cañizo C., Blanco B.. Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development. Journal of Hematology and Oncology. 20 October 2016. DOI: 10.1186/s13045-016-0343-5.
Impacto: 6.35. Cuartil: Q1
(1er decil)
Valencia J., Blanco B., Yáñez R., Vázquez M., Herrero Sánchez C., Fernández-García M., Rodríguez Serrano C., Pescador D., Blanco J.F., Hernando-Rodríguez M., Sánchez-Guijo F., Lamana M.L., Segovia J.C., Vicente Á., Del Cañizo C., Zapata A.G.. Comparative analysis of the immunomodulatory capacities of human bone marrow– and adipose tissue–derived mesenchymal stromal cells from the same donor. Cytotherapy. 1 October 2016. DOI: 10.1016/j.jcyt.2016.07.006.
Impacto: 3.203. Cuartil: Q2
Montero-Herradón S., García-Ceca J., Sánchez del Collado B., Alfaro D., Zapata A.. Eph/ephrin-B-mediated cell-to-cell interactions govern MTS20<sup>+</sup> thymic epithelial cell development. Histochemistry and Cell Biology. 1 August 2016. DOI: 10.1007/s00418-016-1431-x.
Impacto: 2.553. Cuartil: Q1
Herrero-Sánchez M.C., Rodríguez-Serrano C., Almeida J., San-Segundo L., Inogés S., Santos-Briz Á., García-Briñón J., Sanmiguel J.F., Del Cañizo C., Blanco B.. Effect of mTORC1/mTORC2 inhibition on T cell function: Potential role in graft-versus-host disease control. British Journal of Haematology. 1 June 2016. DOI: 10.1111/bjh.13984.
Impacto: 5.67. Cuartil: Q1
Flores M.A., Fortea P., Trinidad E.M., García D., Soler G., Ortuño F.J., Zapata A.G., Alonso-Colmenar L.M.. EphrinA4 plays a critical role in α4 and αL mediated survival of human CLL cells during extravasation. Oncotarget. 2016. DOI: 10.18632/oncotarget.10311.
Impacto: 5.168. Cuartil: Q1
Alfaro D., García-Ceca J., Farias-De-Oliveira D., Terra-Granado E., Montero-Herradón S., Cotta-De-Almeida V., Savino W., Zapata A.. EphB2 and EphB3 play an important role in the lymphoid seeding of murine adult thymus. Journal of Leukocyte Biology. November 2015. DOI: 10.1189/jlb.1HI1114-568R.
Impacto: 4.165. Cuartil: Q1
Bednarek D., González-Rosa J.M., Guzmán-Martínez G., Gutiérrez-Gutiérrez Ó., Aguado T., Sánchez-Ferrer C., Marques I.J., Galardi-Castilla M., de Diego I., Gómez M.J., Cortés A., Zapata A., Jiménez-Borreguero L.J., Mercader N., Flores I.. Telomerase Is Essential for Zebrafish Heart Regeneration. Cell Reports. 8 September 2015. DOI: 10.1016/j.celrep.2015.07.064.
Impacto: 7.87. Cuartil: Q1
Blanco B., Herrero-Sánchez C., Rodríguez-Serrano C., Sánchez-Barba M., Del Cañizo M.C.. Comparative effect of two pan-class i PI3K inhibitors used as anticancer drugs on human T cell function. International Immunopharmacology. 19 August 2015. DOI: 10.1016/j.intimp.2015.07.032.
Impacto: 2.551. Cuartil: Q2
Martínez V., Canseco N., Hidalgo L., Valencia J., Entrena A., Fernández-Sevilla L., Hernández-López C., Sacedón R., Vicente A., Varas A.. A discrete population of IFN λ-expressing BDCA3 hi dendritic cells is present in human thymus. Immunology and Cell Biology. 12 August 2015. DOI: 10.1038/icb.2015.22.
Impacto: 4.473. Cuartil: Q1
Entrena A., Varas A., Vázquez M., Melen G.J., Fernández-Sevilla L.M., García-Castro J., Ramírez M., Zapata A.G., Vicente Á.. Mesenchymal stem cells derived from low risk acute lymphoblastic leukemia patients promote NK cell antitumor activity. Cancer Letters. 28 July 2015. DOI: 10.1016/j.canlet.2015.04.012.
Impacto: 5.992. Cuartil: Q1
Varas A., Valencia J., Lavocat F., Martínez V.G., Thiam N.N., Hidalgo L., Fernández-Sevilla L.M., Sacedón R., Vicente A., Miossec P.. Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-aα combination in rheumatoid synoviocytes. Arthritis Research and Therapy. 28 July 2015. DOI: 10.1186/s13075-015-0710-6.
Impacto: 3.979. Cuartil: Q1
Blanco B., Herrero-Sánchez M., Rodríguez-Serrano C., Sánchez-Barba M., del Cañizo M.. Profound blockade of T cell activation requires concomitant inhibition of different class I PI3K isoforms. Immunologic Research. 26 June 2015. DOI: 10.1007/s12026-015-8648-y.
Impacto: 2.934. Cuartil: Q2
Martínez V., Sacedón R., Hidalgo L., Valencia J., Fernández-Sevilla L., Hernández-López C., Vicente A., Varas A.. The BMP pathway participates in human naive CD4<sup>+</sup> T cell activation and homeostasis. PLoS ONE. 25 June 2015. DOI: 10.1371/journal.pone.0131453.
Impacto: 3.057. Cuartil: Q1
Cejalvo T., Munoz J., Tobajas E., Alfaro D., García-Ceca J., Zapata A.. Conditioned deletion of ephrinB1 and/or ephrinB2 in either thymocytes or thymic epithelial cells alters the organization of thymic medulla and favors the appearance of thymic epithelial cysts. Histochemistry and Cell Biology. 8 April 2015. DOI: 10.1007/s00418-014-1296-9.
Impacto: 2.78. Cuartil: Q1
Valencia J., Martínez V., Hidalgo L., Hernández-López C., Canseco N., Vicente Á., Varas A., Sacedón R.. Wnt5a signaling increases IL-12 secretion by human dendritic cells and enhances IFN-γ production by CD4<sup>+</sup> T cells. Immunology Letters. January 01, 2015. DOI: 10.1016/j.imlet.2014.08.015.
Impacto: 2.483. Cuartil: Q3
Muñoz J.J., Cejalvo T., Tobajas E., Fanlo L., Cortés A., Zapata A.G.. 3D immunofluorescence analysis of early thymic morphogenesis and medulla development. Histology and Histopathology. 2015. DOI: 10.14670/HH-30.589.
Impacto: 1.875. Cuartil: Q3
García-Ceca J., Alfaro D., Montero-Herradón S., Tobajas E., Muñoz J., Zapata A.. Eph/ephrins-mediated thymocyte-thymic epithelial cell interactions control numerous processes of thymus biology. Frontiers in Immunology. 2015. DOI: 10.3389/fimmu.2015.00333.
Impacto: 5.695. Cuartil: Q1
Robson N.C., Hidalgo L., McAlpine T., Wei H., Martínez V.G., Entrena A., Melen G.J., MacDonald A.S., Phythian-Adams A., Sacedón R., Maraskovsky E., Cebon J., Ramírez M., Vicente A., Varas A.. Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling. Cancer Research. 18 July 2014. DOI: 10.1158/0008-5472.CAN-13-2845.
Impacto: 9.329. Cuartil: Q1
(1er decil)
Icardo J., Wong W., Colvee E., Loong A., Zapata A., Ip Y.. Lympho-granulocytic tissue associated with the wall of the spiral valve in the African lungfish Protopterus annectens. Cell and Tissue Research. February 2014. DOI: 10.1007/s00441-013-1746-z.
Impacto: 3.565. Cuartil: Q2
Vicente López A., Vázquez García M.N., Melen G.J., Entrena Martínez A., Cubillo Moreno I., García-Castro J., Ramírez Orellana M., Zapata González A.G.. Mesenchymal stromal cells derived from the bone marrow of acute lymphoblastic leukemia patients show altered BMP4 production: Correlations with the course of disease. PLoS ONE. 6 January 2014. DOI: 10.1371/journal.pone.0084496.
Impacto: 3.234. Cuartil: Q1
Martínez V., Hidalgo L., Valencia J., Hernández-López C., Entrena A., del Amo B., Zapata A., Vicente A., Sacedón R., Varas A.. Autocrine activation of canonical BMP signaling regulates PD-L1 and PD-L2 expression in human dendritic cells. European Journal of Immunology. April 2014. DOI: 10.1002/eji.201343693.
Impacto: 4.034. Cuartil: Q2
Mirones I., Ángel Rodríguez-Milla M., Cubillo I., Mariñas-Pardo L., De La Cueva T., Zapata A., González C., Ramírez M., García-Castro J.. Dopamine mobilizes mesenchymal progenitor cells through d2-class receptors and their pi3k/akt pathway. Stem Cells. September 2014. DOI: 10.1002/stem.1745.
Impacto: 6.523. Cuartil: Q1
(1er decil)
Martinelli P., Cañamero M., Del Pozo N., Madriles F., Zapata A., Real F.X.. Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice. Gut. October 2013. DOI: 10.1136/gutjnl-2012-303328.
Impacto: 13.319. Cuartil: Q1
(1er decil)
Peralta M., Steed E., Harlepp S., González-Rosa J.M., Monduc F., Ariza-Cosano A., Cortés A., Rayón T., Gómez-Skarmeta J.L., Zapata A., Vermot J., Mercader N.. Heartbeat-driven pericardiac fluid forces contribute to epicardium morphogenesis. Current Biology. 23 September 2013. DOI: 10.1016/j.cub.2013.07.005.
Impacto: 9.916. Cuartil: Q1
(1er decil)
Ramos-Medina R., García-Segovia A., León J.A., Alonso B., Tejera-Alhambra M., Gil J., Caputo J.D., Seyfferth A., Aguarón A., Vicente A., Ordoñez D., Alonso J., de Albornoz E.C., Carbone J., Caballero P., Fernandez-Cruz E., Ortiz-Quintana L., Sánchez-Ramón S.. New decision-tree model for defining the risk of reproductive failure. American Journal of Reproductive Immunology. July 2013. DOI: 10.1111/aji.12098.
Impacto: 2.668. Cuartil: Q3
Cejalvo T., Munoz J., Tobajas E., Fanlo L., Alfaro D., Javier G., Zapata A.. Ephrin-B-dependent thymic epithelial cell-thymocyte interactions are necessary for correct T Cell differentiation and thymus histology organization: Relevance for thymic cortex development. Journal of Immunology. 15 March 2013. DOI: 10.4049/jimmunol.1201931.
Impacto: 5.362. Cuartil: Q1
García-Ceca J., Alfaro D., Montero-Herradón S., Zapata A.. Eph/ephrinB signalling is involved in the survival of thymic epithelial cells. Immunology and Cell Biology. February 2013. DOI: 10.1038/icb.2012.59.
Impacto: 4.205. Cuartil: Q1
Peces-Peña M.D., De La Cuadra-Blanco C., Vicente A., Mérida-Velasco J.R.. Development of the ciliary body: Morphological changes in the distal portion of the optic cup in the human. Cells Tissues Organs. 16 April 2013. DOI: 10.1159/000353648.
Impacto: 2.138. Cuartil: Q2
Mendes-Da-Cruz D.A., Stimamiglio M.A., Muñoz J.J., Alfaro D., Terra-Granado E., Garcia-Ceca J., Alonso-Colmenar L.M., Savino W., Zapata A.G.. Developing T-cell migration: Role of semaphorins and ephrins. FASEB Journal. November 2012. DOI: 10.1096/fj.11-202952.
Santamaría C., Muntión S., Rosón B., Blanco B., López-Villar O., Carrancio S., Sánchez-Guijo F.M., Díez-Campelo M., Alvarez-Fernández S., Sarasquete M.E., de las Rivas J., González M., Miguel J.F.S., del Cañizo M.C.. Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients. Haematologica. 1 August 2012. DOI: 10.3324/haematol.2011.054437.
Impacto: 5.935. Cuartil: Q1
Gutierrez-Cosío S., de la Rica L., Ballestar E., Santamaría C., Sánchez-Abarca L.I., Caballero-Velazquez T., Blanco B., Calderón C., Herrero-Sánchez C., Carrancio S., Ciudad L., Cañizo C., Miguel J.F.S., Pérez-Simón J.A.. Epigenetic regulation of PRAME in acute myeloid leukemia is different compared to CD34+ cells from healthy donors: Effect of 5-AZA treatment. Leukemia Research. July 2012. DOI: 10.1016/j.leukres.2012.02.030.
Impacto: 2.764. Cuartil: Q2
Zapata A.G., Alfaro D., García-Ceca J.. Biology of stem cells: The role of microenvironments. Advances in Experimental Medicine and Biology. 2012. DOI: 10.1007/978-1-4614-2098-9_10.
Impacto: 1.825. Cuartil: Q2
Hidalgo L., Martínez V.G., Valencia J., Hernández-López C., Vázquez M.N., Nuñez J.R., Zapata A.G., Sacedón R., Varas A., Vicente A.. Expression of BMPRIA on human thymic NK cell precursors: Role of BMP signaling in intrathymic NK cell development. Blood. 23 February 2012. DOI: 10.1182/blood-2011-07-370650.
Impacto: 9.06. Cuartil: Q1
(1er decil)
Caballero-Velázquez T., Sánchez-Abarca L.I., Gutierrez-Cosio S., Blanco B., Calderon C., Herrero C., Carrancio S., Serrano C., del Cañizo C., San Miguel J.F., Pérez-Simón J.A.. The novel combination of sirolimus and bortezomib prevents graft-versus-host disease but maintains the graft-versus-leukemia effect after allogeneic transplantation. Haematologica. 20120901. DOI: 10.3324/haematol.2011.058677.
Impacto: 5.935. Cuartil: Q1
Alfaro D., Mũoz J., García-Ceca J., Cejalvo T., Jiménez E., Zapata A.. The Eph/ephrinB signal balance determines the pattern of T-cell maturation in the thymus. Immunology and Cell Biology. November 2011. DOI: 10.1038/icb.2010.172.
Impacto: 3.661. Cuartil: Q2
Carrancio S., Blanco B., Romo C., Muntion S., Lopez-Holgado N., Blanco J.F., Briñon J.G., Miguel J.F.S., Sanchez-Guijo F.M., del Cañizo M.C.. Bone marrow mesenchymal stem cells for improving hematopoietic function: An in vitro and in vivo model. Part 2: Effect on bone marrow microenvironment. PLoS ONE. 2011. DOI: 10.1371/journal.pone.0026241.
Impacto: 4.092. Cuartil: Q1
Valencia J., Hernández-López C., Martínez V., Hidalgo L., Zapata A., Vicente A., Varas A., Sacedón R.. Wnt5a skews dendritic cell differentiation to an unconventional phenotype with tolerogenic features. Journal of Immunology. 15 October 2011. DOI: 10.4049/jimmunol.1101243.
Impacto: 5.788. Cuartil: Q1
Blanco B., Sánchez-Abarca L.I., Caballero-Velázquez T., Santamaría C., Inogés S., Pérez-Simón J.A.. Depletion of alloreactive T-cells in vitro using the proteasome inhibitor bortezomib preserves the immune response against pathogens. Leukemia Research. October 2011. DOI: 10.1016/j.leukres.2011.05.018.
Impacto: 2.923. Cuartil: Q2
Muñoz J., Cejalvo T., Alonso-Colmenar L., Alfaro D., Garcia-Ceca J., Zapata A.. Eph/ephrin-mediated interactions in the thymus. NeuroImmunoModulation. September 2011. DOI: 10.1159/000329490.
Impacto: 2.383. Cuartil: Q3
Martínez V., Hernández-López C., Valencia J., Hidalgo L., Entrena A., Zapata A., Vicente A., Sacedón R., Varas A.. The canonical BMP signaling pathway is involved in human monocyte-derived dendritic cell maturation. Immunology and Cell Biology. July 2011. DOI: 10.1038/icb.2010.135.
Impacto: 3.661. Cuartil: Q2
Vicente López M., Vázquez García M., Entrena A., Olmedillas Lopez S., García-Arranz M., García-Olmo D., Zapata A.. Low doses of bone morphogenetic protein 4 increase the survival of human adipose-derived stem cells maintaining their stemness and multipotency. Stem Cells and Development. 1 June 2011. DOI: 10.1089/scd.2010.0355.
Impacto: 4.459. Cuartil: Q1
(1er decil)
Pérez R.L., Pérez-Simón J.A., Caballero-Velazquez T., Flores T., Carrancio S., Herrero C., Blanco B., Gutierrez-Cosio S., Cañete-Campos C., Cruz González F., San-Miguel J.F., Hernández-Galilea E., Sánchez-Abarca I.. Limbus Damage in Ocular Graft-versus-Host Disease. Biology of Blood and Marrow Transplantation. February 2011. DOI: 10.1016/j.bbmt.2010.08.008.
Impacto: 3.873. Cuartil: Q1
Zapata A.. Bone-marrow stroma: A source of mesenchymal stem cells for cell therapy. Stem Cells in Reproductive Medicine: Basic Science and Therapeutic Potential. 1 January 2011. DOI: 10.1017/CBO9781139540742.014.