Investigadores
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Investigadores
Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Terapia Génica
Desarrollos Tecnológicos y Terapéuticos
Assumpció BOSCH MERINO
Investigador principal
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Miguel CHILLON RODRIGUEZ
Investigador principal
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Alejandro Brao González
Investigador colaborador
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Ángel Edo Salvador
Investigador colaborador
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Ángela Sánchez Osunaº
Investigador colaborador
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Beatriz Almolda Ardid
Investigador colaborador
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Joan Roig Soriano
Investigador colaborador
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Jon Esandi Jauregui
Investigador colaborador
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Laura Rodriguez Estevez
Investigador colaborador
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Rubén Guerrero Yagüe
Investigador colaborador
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Rubèn Lopez Vales
Investigador colaborador
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Sergi Verdés Franquesa
Investigador colaborador
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Susana Miravet Delgado
Investigador colaborador
Grupo de Investigación: Instituto de Neurociencias. Universidad Autónoma de Barcelona. (UAB)
Esandi J., Renault P., Capilla-López M.D., Blanch R., Edo Á., Ramirez-Gómez D., Bosch A., Almolda B., Saura C.A., Giraldo J., Chillón M.. HEBE: A novel chimeric chronokine for ameliorating memory deficits in Alzheimer's disease. Biomedicine and Pharmacotherapy. February 2025. DOI: 10.1016/j.biopha.2025.117815.
Impacto: 6.9. Cuartil: Q1
(1er decil)
Vasireddy V., Maguire C.A., Anderson D.W., Ng C., Gong Y., Eichler F., Fourcade S., Guilera C., Onieva A., Sanchez A., Leal-Julià M., Verdés S., Dijkstra I.M.E., Kemp S., Park H.G., Lutz T., Clark S.W., Bosch A., Pujol A., Kozarsky K.. An in vitro and in vivo efficacy evaluation of gene therapy candidate SBT101 in mouse models of adrenomyeloneuropathy and in NHPs. Molecular Therapy Methods and Clinical Development. 12 December 2024. DOI: 10.1016/j.omtm.2024.101354.
Ciudad C.J., Valiuska S., Rojas J.M., Nogales-Altozano P., Aviñó A., Eritja R., Chillón M., Sevilla N., Noé V.. Polypurine reverse hoogsteen hairpins as a therapeutic tool for SARS-CoV-2 infection. Journal of Biological Chemistry. November 2024. DOI: 10.1016/j.jbc.2024.107884.
Impacto: 4.0. Cuartil: Q2
Amo-Aparicio J., Dinarello C.A., Lopez-Vales R.. Metabolic reprogramming of the inflammatory response in the nervous system: the crossover between inflammation and metabolism. Neural Regeneration Research. October 2024. DOI: 10.4103/1673-5374.391330.
Impacto: 5.9. Cuartil: Q1
Bunuales M., Garduno A., Chillon M., Bosch A., Gonzalez-Aparicio M., Espelosin M., Garcia-Gomara M., Rico A.J., Garcia-Osta A., Cuadrado-Tejedor M., Lanciego J.L., Hernandez-Alcoceba R.. Characterization of brain transduction capability of a BBB-penetrant AAV vector in mice, rats and macaques reveals differences in expression profiles. Gene Therapy. September 2024. DOI: 10.1038/s41434-024-00466-w.
Impacto: 4.6. Cuartil: Q1
Fitzgerald M.Q., Chu T., Puppo F., Blanch R., Chillón M., Subramaniam S., Muotri A.R.. Generation of ‘semi-guided’ cortical organoids with complex neural oscillations. Nature Protocols. September 2024. DOI: 10.1038/s41596-024-00994-0.
Impacto: 13.1. Cuartil: Q1
(1er decil)
Favaro M.T.P., Alamo P., Roher N., Chillon M., Lascorz J., Márquez M., Corchero J.L., Mendoza R., Martínez-Torró C., Ferrer-Miralles N., Ferreira L.C.S., Mangues R., Vázquez E., Parladé E., Villaverde A.. Zinc-Assisted Microscale Granules Made of the SARS-CoV-2 Spike Protein Trigger Neutralizing, Antivirus Antibody Responses. ACS Materials Letters. 4 March 2024. DOI: 10.1021/acsmaterialslett.3c01643.
Impacto: 9.6. Cuartil: Q1
Fitzgerald M.Q., Chu T., Puppo F., Blanch R., Chillón M., Subramaniam S., Muotri A.R.. Publisher Correction: Generation of ‘semi-guided’ cortical organoids with complex neural oscillations (Nature Protocols, (2024), 19, 9, (2712-2738), 10.1038/s41596-024-00994-0). Nature Protocols. 2024. DOI: 10.1038/s41596-024-01087-8.
Impacto: 13.1. Cuartil: Q1
(1er decil)
Roig-Soriano J., Sánchez-de-Diego C., Esandi-Jauregui J., Verdés S., Abraham C.R., Bosch A., Ventura F., Chillón M.. Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure. Scientific Reports. December 2023. DOI: 10.1038/s41598-023-31117-6.
Impacto: 3.8. Cuartil: Q1
Kagiava A., Karaiskos C., Lapathitis G., Heslegrave A., Sargiannidou I., Zetterberg H., Bosch A., Kleopa K.A.. Gene replacement therapy in two Golgi-retained CMT1X mutants before and after the onset of demyelinating neuropathy. Molecular Therapy Methods and Clinical Development. 14 September 2023. DOI: 10.1016/j.omtm.2023.07.011.
Peris M., Benseny-Cases N., Manich G., Zerpa O., Almolda B., Perálvarez-Marín A., González B., Castellano B.. Roadmap for Postnatal Brain Maturation: Changes in Gray and White Matter Composition during Development Measured by Fourier Transformed Infrared Microspectroscopy. ACS Chemical Neuroscience. 6 September 2023. DOI: 10.1021/acschemneuro.3c00237.
Impacto: 4.1. Cuartil: Q2
Sánchez-Fernández A., Zandee S., Mastrogiovanni M., Charabati M., Rubbo H., Prat A., López-Vales R.. Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. December 2022. DOI: 10.1186/s12974-022-02386-1.
Impacto: 9.3. Cuartil: Q1
Companys-Alemany J., Roig-Soriano J., Turcu A.L., Chillón M., Vázquez S., Pallàs M., Griñán-Ferré C.. Optimized N-methyl-D-aspartate receptor antagonist exhibits hippocampal proneurogenic effects in aged senescence-accelerated mouse prone 8 mice. NeuroReport. 5 October 2022. DOI: 10.1097/WNR.0000000000001825.
Impacto: 1.7. Cuartil: Q4
Edo Á., Calvo-Barreiro L., Eixarch H., Bosch A., Chillón M., Espejo C.. Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis. Neurotherapeutics. September 2022. DOI: 10.1007/s13311-022-01279-8.
Impacto: 5.7. Cuartil: Q1
Khiar-Fernández N., Zian D., Vázquez-Villa H., Martínez R.F., Escobar-Peña A., Foronda-Sainz R., Ray M., Puigdomenech-Poch M., Cincilla G., Sánchez-Martínez M., Kihara Y., Chun J., López-Vales R., López-Rodríguez M.L., Ortega-Gutiérrez S.. Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA<inf>2</inf>), UCM-14216, Ameliorates Spinal Cord Injury in Mice. Journal of Medicinal Chemistry. 25 August 2022. DOI: 10.1021/acs.jmedchem.2c00046.
Impacto: 7.3. Cuartil: Q1
(1er decil)
Shanaki-Barvasad M., Almolda B., González B., Castellano B.. Astrocyte-targeted Overproduction of IL-10 Reduces Neurodegeneration after TBI. Experimental Neurobiology. 1 June 2022. DOI: 10.5607/en21035.
Impacto: 2.4. Cuartil: Q3
Pannunzio B., Amo-Aparicio J., Julián C., López-Vales R., Peluffo H., Lago N.. CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury. Cells. June-1 2022. DOI: 10.3390/cells11111786.
Impacto: 6.0. Cuartil: Q2
Enrich-Bengoa J., Manich G., Valente T., Sanchez-Molina P., Almolda B., Solà C., Saura J., González B., Castellano B., Perálvarez-Marín A.. TRPV2: A Key Player in Myelination Disorders of the Central Nervous System. International Journal of Molecular Sciences. April-1 2022. DOI: 10.3390/ijms23073617.
Impacto: 5.6. Cuartil: Q1
Roig-Soriano J., Griñán-Ferré C., Espinosa-Parrilla J.F., Abraham C.R., Bosch A., Pallàs M., Chillón M.. AAV-mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice. Aging Cell. April 2022. DOI: 10.1111/acel.13581.
Impacto: 7.8. Cuartil: Q1
(1er decil)
Sanchez-Molina P., Almolda B., Giménez-Llort L., González B., Castellano B.. Chronic IL-10 overproduction disrupts microglia-neuron dialogue similar to aging, resulting in impaired hippocampal neurogenesis and spatial memory. Brain, Behavior, and Immunity. March 2022. DOI: 10.1016/j.bbi.2021.12.026.
Impacto: 15.1. Cuartil: Q1
(1er decil)
Mastrogiovanni M., Trostchansky A., Naya H., Dominguez R., Marco C., Povedano M., López-Vales R., Rubbo H.. HPLC-MS/MS Oxylipin Analysis of Plasma from Amyotrophic Lateral Sclerosis Patients. Biomedicines. March 2022. DOI: 10.3390/biomedicines10030674.
Impacto: 4.7. Cuartil: Q1
Leal-Julià M., Vilches J.J., Onieva A., Verdés S., Sánchez Á., Chillón M., Navarro X., Bosch A.. Proteomic quantitative study of dorsal root ganglia and sciatic nerve in type 2 diabetic mice. Molecular Metabolism. January 2022. DOI: 10.1016/j.molmet.2021.101408.
Impacto: 8.1. Cuartil: Q1
(1er decil)
Amo-Aparicio J., Garcia-Garcia J., Puigdomenech M., Francos-Quijorna I., Skouras D.B., Dinarello C.A., Lopez-Vales R.. Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury. Experimental Neurology. January 2022. DOI: 10.1016/j.expneurol.2021.113889.
Impacto: 5.3. Cuartil: Q1
Rubinstein T.A., Reuveni I., Hesin A., Klein-Goldberg A., Olauson H., Larsson T.E., Abraham C.R., Zeldich E., Bosch A., Chillón M., Hollander K.S., Shabtay-Orbach A., Vainer G.W., Wolf I., Rubinek T.. A transgenic model reveals the role of klotho in pancreatic cancer development and paves the way for new klotho-based therapy. Cancers. December-2 2021. DOI: 10.3390/cancers13246297.
Impacto: 6.575. Cuartil: Q1
Recasens M., Almolda B., Pérez-Clausell J., Campbell I.L., González B., Castellano B.. Chronic exposure to IL-6 induces a desensitized phenotype of the microglia. Journal of Neuroinflammation. December 2021. DOI: 10.1186/s12974-020-02063-1.
Impacto: 9.587. Cuartil: Q1
(1er decil)
Kagiava A., Richter J., Tryfonos C., Leal-Julià M., Sargiannidou I., Christodoulou C., Bosch A., Kleopa K.A.. Efficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery. Scientific Reports. December 2021. DOI: 10.1038/s41598-021-02694-1.
Impacto: 4.996. Cuartil: Q2
Milian L., Sancho-Tello M., Roig-Soriano J., Foschini G., Martínez-Hernández N.J., Más-Estellés J., Ruiz-Sauri A., Zurriaga J., Carda C., Mata M.. Optimization of a decellularization protocol of porcine tracheas. Long-term effects of cryopreservation. A histological study. International Journal of Artificial Organs. December 2021. DOI: 10.1177/03913988211008912.
Impacto: 1.631. Cuartil: Q3
Mòdol-Caballero G., Herrando-Grabulosa M., Verdés S., García-Lareu B., Hernández N., Francos-Quijorna I., López-Vales R., Bosch A., Navarro X.. Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1<sup>G93A</sup> ALS Mice. Frontiers in Neurology. 22 September 2021. DOI: 10.3389/fneur.2021.693309.
Impacto: 4.086. Cuartil: Q2
Aubets E., Chillon M., Ciudad C.J., Noé V.. Polypurine reverse hoogsteen hairpins work as rna species for gene silencing. International Journal of Molecular Sciences. September 2021. DOI: 10.3390/ijms221810025.
Impacto: 6.208. Cuartil: Q1
Sanchez-Molina P., Almolda B., Benseny-Cases N., González B., Perálvarez-Marín A., Castellano B.. Specific microglial phagocytic phenotype and decrease of lipid oxidation in white matter areas during aging: Implications of different microenvironments. Neurobiology of Aging. September 2021. DOI: 10.1016/j.neurobiolaging.2021.03.015.
Impacto: 5.133. Cuartil: Q2
Leiva-Rodríguez T., Romeo-Guitart D., Herrando-Grabulosa M., Muñoz-Guardiola P., Polo M., Bañuls C., Petegnief V., Bosch A., Lizcano J.M., Apostolova N., Forés J., Casas C.. Grp78 overexpression triggers pink1-ip<inf>3</inf> r-mediated neuroprotective mitophagy. Biomedicines. August 2021. DOI: 10.3390/biomedicines9081039.
Impacto: 4.757. Cuartil: Q2
David S., López-Vales R.. Bioactive Lipid Mediators in the Initiation and Resolution of Inflammation after Spinal Cord Injury. Neuroscience. 1 July 2021. DOI: 10.1016/j.neuroscience.2021.04.026.
Impacto: 3.708. Cuartil: Q3
Hernández J., Francos-Quijorna I., Redondo-Castro E., López-Vales R., Navarro X.. Microglia Stimulation by Protein Extract of Injured Rat Spinal Cord. A Novel In vitro Model for Studying Activated Microglia. Frontiers in Molecular Neuroscience. 20 May 2021. DOI: 10.3389/fnmol.2021.582497.
Impacto: 6.261. Cuartil: Q1
Griñán-Ferré C., Bellver-Sanchis A., Izquierdo V., Corpas R., Roig-Soriano J., Chillón M., Andres-Lacueva C., Somogyvári M., Sőti C., Sanfeliu C., Pallàs M.. The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: From antioxidant to epigenetic therapy. Ageing Research Reviews. May 2021. DOI: 10.1016/j.arr.2021.101271.
Impacto: 11.788. Cuartil: Q1
(1er decil)
Mòdol-Caballero G., García-Lareu B., Herrando-Grabulosa M., Verdés S., López-Vales R., Pagès G., Chillón M., Navarro X., Bosch A.. Specific Expression of Glial-Derived Neurotrophic Factor in Muscles as Gene Therapy Strategy for Amyotrophic Lateral Sclerosis. Neurotherapeutics. April 2021. DOI: 10.1007/s13311-021-01025-6.
Impacto: 6.088. Cuartil: Q1
Puigdomenech-Poch M., Martínez-Muriana A., Andrés-Benito P., Ferrer I., Chun J., López-Vales R.. Dual Role of Lysophosphatidic Acid Receptor 2 (LPA<inf>2</inf>) in Amyotrophic Lateral Sclerosis. Frontiers in Cellular Neuroscience. 25 March 2021. DOI: 10.3389/fncel.2021.600872.
Impacto: 6.147. Cuartil: Q1
Gómez-López A.R., Manich G., Recasens M., Almolda B., González B., Castellano B.. Evaluation of Myelin Phagocytosis by Microglia/Macrophages in Nervous Tissue Using Flow Cytometry. Current Protocols. March 2021. DOI: 10.1002/cpz1.73.
Vogel-González M., Talló-Parra M., Herrera-Fernández V., Pérez-Vilaró G., Chillón M., Nogués X., Gómez-Zorrilla S., López-Montesinos I., Arnau-Barrés I., Sorli-Redó M.L., Horcajada J.P., García-Giralt N., Pascual J., Díez J., Vicente R., Güerri-Fernández R.. Low zinc levels at admission associates with poor clinical outcomes in sars-cov-2 infection. Nutrients. February 2021. DOI: 10.3390/nu13020562.
Impacto: 6.706. Cuartil: Q1
Bosch A., Estévez R.. Megalencephalic Leukoencephalopathy: Insights Into Pathophysiology and Perspectives for Therapy. Frontiers in Cellular Neuroscience. 22 January 2021. DOI: 10.3389/fncel.2020.627887.
Impacto: 6.147. Cuartil: Q1
Amo-Aparicio J., Garcia-Garcia J., Francos-Quijorna I., Urpi A., Esteve-Codina A., Gut M., Quintana A., Lopez-Vales R.. Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury. Theranostics. 2021. DOI: 10.7150/thno.65203.
Impacto: 11.6. Cuartil: Q1
(1er decil)
Amo-Aparicio J., Sanchez-Fernandez A., Li S., Eisenmesser E.Z., Garlanda C., Dinarello C.A., Lopez-Vales R.. Extracellular and nuclear roles of IL-37 after spinal cord injury. Brain, Behavior, and Immunity. January 2021. DOI: 10.1016/j.bbi.2020.09.026.
Impacto: 19.227. Cuartil: Q1
(1er decil)
Manich G., Gómez-López A.R., Almolda B., Villacampa N., Recasens M., Shrivastava K., González B., Castellano B.. Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models. Frontiers in Cellular Neuroscience. 20 November 2020. DOI: 10.3389/fncel.2020.567404.
Impacto: 5.505. Cuartil: Q1
Rønholt K., Nielsen A.L.L., Johansen C., Vestergaard C., Fauerbye A., López-Vales R., Dinarello C.A., Iversen L.. IL-37 Expression Is Downregulated in Lesional Psoriasis Skin. ImmunoHorizons. 1 November 2020. DOI: 10.4049/immunohorizons.2000083.
Sánchez A., García-Lareu B., Puig M., Prat E., Ruberte J., Chillón M., Nunes V., Estévez R., Bosch A.. Cerebellar Astrocyte Transduction as Gene Therapy for Megalencephalic Leukoencephalopathy. Neurotherapeutics. October 2020. DOI: 10.1007/s13311-020-00865-y.
Impacto: 7.62. Cuartil: Q1
(1er decil)
Sanchez-Molina P., Kreuzer M., Benseny-Cases N., Valente T., Almolda B., González B., Castellano B., Perálvarez-Marín A.. From mouse to human: Comparative analysis between grey and white matter by synchrotron-fourier transformed infrared microspectroscopy. Biomolecules. August 2020. DOI: 10.3390/biom10081099.
Impacto: 4.879. Cuartil: Q2
Mòdol-Caballero G., García-Lareu B., Verdés S., Ariza L., Sánchez-Brualla I., Brocard F., Bosch A., Navarro X., Herrando-Grabulosa M.. Therapeutic Role of Neuregulin 1 Type III in SOD1-Linked Amyotrophic Lateral Sclerosis. Neurotherapeutics. 1 July 2020. DOI: 10.1007/s13311-019-00811-7.
Impacto: 7.62. Cuartil: Q1
(1er decil)
Mòdol-Caballero G., Herrando-Grabulosa M., García-Lareu B., Solanes N., Verdés S., Osta R., Francos-Quijorna I., López-Vales R., Calvo A.C., Bosch A., Navarro X.. Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1<sup>G93A</sup> ALS mice. Neurobiology of Disease. April 2020. DOI: 10.1016/j.nbd.2020.104793.
Impacto: 5.996. Cuartil: Q1
Amorós-Aguilar L., Portell-Cortés I., Costa-Miserachs D., Torras-Garcia M., Riubugent-Camps È., Almolda B., Coll-Andreu M.. The benefits of voluntary physical exercise after traumatic brain injury on rat's object recognition memory: A comparison of different temporal schedules. Experimental Neurology. April 2020. DOI: 10.1016/j.expneurol.2020.113178.
Impacto: 5.33. Cuartil: Q2
Lago N., Kaufmann F.N., Negro-Demontel M.L., Alí-Ruiz D., Ghisleni G., Rego N., Arcas-García A., Vitureira N., Jansen K., Souza L.M., Silva R.A., Lara D.R., Pannunzio B., Abin-Carriquiry J.A., Amo-Aparicio J., Martin-Otal C., Naya H., McGavern D.B., Sayós J., López-Vales R., Kaster M.P., Peluffo H.. CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness. Proceedings of the National Academy of Sciences of the United States of America. 24 March 2020. DOI: 10.1073/pnas.1911816117.
Impacto: 11.205. Cuartil: Q1
González-Gil I., Zian D., Vázquez-Villa H., Hernández-Torres G., Martínez R.F., Khiar-Fernández N., Rivera R., Kihara Y., Devesa I., Mathivanan S., Del Valle C.R., Zambrana-Infantes E., Puigdomenech M., Cincilla G., Sanchez-Martinez M., Rodríguez De Fonseca F., Ferrer-Montiel A.V., Chun J., López-Vales R., López-Rodríguez M.L., Ortega-Gutiérrez S.. A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA<inf>1</inf>), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration. Journal of Medicinal Chemistry. 12 March 2020. DOI: 10.1021/acs.jmedchem.9b01287.
Impacto: 7.446. Cuartil: Q1
(1er decil)
Martínez-Muriana A., Pastor D., Mancuso R., Rando A., Osta R., Martínez S., López-Vales R., Navarro X.. Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1<sup>G93A</sup> mice. Stem Cell Research and Therapy. 7 February 2020. DOI: 10.1186/s13287-020-1573-6.
Impacto: 6.832. Cuartil: Q1
Sánchez-Fernández A., Zandee S., Amo-Aparicio J., Charabati M., Prat A., Garlanda C., Eisenmesser E.Z., Dinarello C.A., López-Vales R.. IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8. Theranostics. 2020. DOI: 10.7150/THNO.47435.
Impacto: 11.556. Cuartil: Q1
(1er decil)
Bosch A., Chillon M.. Gene therapy approaches in central nervous system regenerative medicine. Handbook of Innovations in Central Nervous System Regenerative Medicine. 1 January 2020. DOI: 10.1016/B978-0-12-818084-6.00010-6.
Pagès G., Giménez-Llort L., García-Lareu B., Ariza L., Navarro M., Casas C., Chillón M., Bosch A.. Intrathecal AAVrh10 corrects biochemical and histological hallmarks of mucopolysaccharidosis VII mice and improves behavior and survival. Human Molecular Genetics. 1 November 2019. DOI: 10.1093/hmg/ddz220.
Impacto: 5.101. Cuartil: Q1
Sánchez-Fernández A., Skouras D.B., Dinarello C.A., López-Vales R.. OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis. Frontiers in Immunology. 1 November 2019. DOI: 10.3389/fimmu.2019.02578.
Impacto: 5.085. Cuartil: Q1
Manich G., Recasens M., Valente T., Almolda B., González B., Castellano B.. Role of the CD200-CD200R Axis During Homeostasis and Neuroinflammation. Neuroscience. 1 May 2019. DOI: 10.1016/j.neuroscience.2018.10.030.
Impacto: 3.056. Cuartil: Q2
Lopez-Font I., Sogorb-Esteve A., Javier-Torrent M., Brinkmalm G., Herrando-Grabulosa M., García-Lareu B., Turon-Sans J., Rojas-García R., Lleó A., Saura C.A., Zetterberg H., Blennow K., Bosch A., Navarro X., Sáez-Valero J.. Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis. Neurobiology of Disease. April 2019. DOI: 10.1016/j.nbd.2018.12.021.
Impacto: 5.332. Cuartil: Q1
Recasens M., Shrivastava K., Almolda B., González B., Castellano B.. Astrocyte-targeted IL-10 production decreases proliferation and induces a downregulation of activated microglia/macrophages after PPT. GLIA. April 2019. DOI: 10.1002/glia.23573.
Impacto: 5.984. Cuartil: Q1
López-Serrano C., Santos-Nogueira E., Francos-Quijorna I., Coll-Miró M., Chun J., López-Vales R.. Lysophosphatidic acid receptor type 2 activation contributes to secondary damage after spinal cord injury in mice. Brain, Behavior, and Immunity. February 2019. DOI: 10.1016/j.bbi.2018.12.007.
Impacto: 6.633. Cuartil: Q1
(1er decil)
Li S., Amo-Aparicio J., Neff C.P., Tengesdal I.W., Azam T., Palmer B.E., López-Vales R., Bufler P., Dinarello C.A.. Role for nuclear interleukin-37 in the suppression of innate immunity. Proceedings of the National Academy of Sciences of the United States of America. 2019. DOI: 10.1073/pnas.1821111116.
Impacto: 9.412. Cuartil: Q1
López-Vales R., David S.. Bioactive lipids in inflammation after central nervous system injury. Advances in Experimental Medicine and Biology. 2019. DOI: 10.1007/978-3-030-11488-6_12.
Impacto: 2.45. Cuartil: Q2
Bayó-Puxan N., Terrasso A.P., Creyssels S., Simão D., Begon-Pescia C., Lavigne M., Salinas S., Bernex F., Bosch A., Kalatzis V., Levade T., Cuervo A.M., Lory P., Consiglio A., Brito C., Kremer E.J.. Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons. Scientific Reports. 1 December 2018. DOI: 10.1038/s41598-018-34523-3.
Impacto: 4.011. Cuartil: Q1
Romeo-Guitart D., Forés J., Herrando-Grabulosa M., Valls R., Leiva-Rodríguez T., Galea E., González-Pérez F., Navarro X., Petegnief V., Bosch A., Coma M., Mas J.M., Casas C.. Neuroprotective Drug for Nerve Trauma Revealed Using Artificial Intelligence. Scientific Reports. 1 December 2018. DOI: 10.1038/s41598-018-19767-3.
Impacto: 4.011. Cuartil: Q1
Amo-Aparicio J., Martínez-Muriana A., Sánchez-Fernández A., López-Vales R.. Neuroinflammation Quantification for Spinal Cord Injury. Current Protocols in Immunology. November 2018. DOI: 10.1002/cpim.57.
Lago N., Pannunzio B., Amo-Aparicio J., López-Vales R., Peluffo H.. CD200 modulates spinal cord injury neuroinflammation and outcome through CD200R1. Brain, Behavior, and Immunity. October 2018. DOI: 10.1016/j.bbi.2018.06.002.
Impacto: 6.17. Cuartil: Q1
(1er decil)
Massó A., Sánchez A., Bosch A., Giménez-Llort L., Chillón M.. Secreted αKlotho isoform protects against age-dependent memory deficits. Molecular Psychiatry. 1 September 2018. DOI: 10.1038/mp.2017.211.
Impacto: 11.973. Cuartil: Q1
(1er decil)
David S., Kroner A., Greenhalgh A.D., Zarruk J.G., López-Vales R.. Myeloid cell responses after spinal cord injury. Journal of Neuroimmunology. 15 August 2018. DOI: 10.1016/j.jneuroim.2018.06.003.
Impacto: 2.832. Cuartil: Q3
Leiva-Rodríguez T., Romeo-Guitart D., Marmolejo-Martínez-Artesero S., Herrando-Grabulosa M., Bosch A., Forés J., Casas C.. ATG5 overexpression is neuroprotective and attenuates cytoskeletal and vesicle-Trafficking alterations in axotomized motoneurons article. Cell Death and Disease. 1 June 2018. DOI: 10.1038/s41419-018-0682-y.
Impacto: 5.959. Cuartil: Q1
Francos-Quijorna I., Santos-Nogueira E., Gronert K., Sullivan A.B., Kopp M.A., Brommer B., David S., Schwab J.M., López-Vales R.. Maresin 1 promotes inflammatory resolution, neuroprotection, and functional neurological recovery after spinal cord injury. Journal of Neuroscience. 29 November 2017. DOI: 10.1523/JNEUROSCI.1395-17.2017.
Impacto: 5.97. Cuartil: Q1
Edo A., Espinosa-Parrilla J.F.. Soluble interleukin 23 receptor gene therapy with adeno-associated vectors for the treatment of multiple sclerosis. Neural Regeneration Research. October 2017. DOI: 10.4103/1673-5374.217327.
Impacto: 2.234. Cuartil: Q3
Miralles M., Eixarch H., Tejero M., Costa C., Hirota K., Castaño A.R., Puig M., Stockinger G., Montalban X., Bosch A., Espejo C., Chillon M.. Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor. Neurotherapeutics. 1 October 2017. DOI: 10.1007/s13311-017-0545-8.
Impacto: 5.719. Cuartil: Q1
(1er decil)
Francos-Quijorna I., Amo-Aparicio J., Martinez-Muriana A., López-Vales R.. IL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury. GLIA. 1 December 2016. DOI: 10.1002/glia.23041.
Impacto: 6.2. Cuartil: Q1
(1er decil)
Solanas G., Miravet S., Casagolda D., Castaño J., Raurell I., Corrionero A., García De Herreros A., Duñach M.. Erratum: β-Catenin and plakoglobin N- and C-tails determine ligand specificity (Journal of Biological Chemistry (2016) 279 (49849-49856) DOI: 10.1074/jbc.M408685200). Journal of Biological Chemistry. 11 November 2016. DOI: 10.1074/jbc.A116.408685.
Impacto: 4.125. Cuartil: Q2
Mancuso R., Martínez-Muriana A., Leiva T., Gregorio D., Ariza L., Morell M., Esteban-Pérez J., García-Redondo A., Calvo A.C., Atencia-Cibreiro G., Corfas G., Osta R., Bosch A., Navarro X.. Neuregulin-1 promotes functional improvement by enhancing collateral sprouting in SOD1<sup>G93A</sup> ALS mice and after partial muscle denervation. Neurobiology of Disease. 1 November 2016. DOI: 10.1016/j.nbd.2016.07.023.
Impacto: 5.02. Cuartil: Q1
Castellano B., Bosch-Queralt M., Almolda B., Villacampa N., González B.. Purine signaling and microglial wrapping. Advances in Experimental Medicine and Biology. 1 October 2016. DOI: 10.1007/978-3-319-40764-7_7.
Impacto: 1.881. Cuartil: Q2
Castaño J., Raurell I., Piedra J.A., Miravet S., Duñach M., De Herreros A.G.. Erratum: β-Catenin N- and C-terminal tails modulate the coordinated binding of adherens junction proteins to β-catenin (The Journal of Biological Chemistry (2002) 277 (31541-31550)). Journal of Biological Chemistry. 20 May 2016. DOI: 10.1074/jbc.A116.204376.
Impacto: 4.125. Cuartil: Q2
Piedra J., Martínez D., Castaño J., Miravet S., Duñach M., De Herreros A.G.. Erratum: Regulation of β-catenin structure and activity by tyrosine phosphorylation (The Journal of Biological Chemistry 276 (2001) 20436-20443). Journal of Biological Chemistry. 20 May 2016. DOI: 10.1074/jbc.A116.100194.
Impacto: 4.125. Cuartil: Q2
Martínez-Muriana A., Mancuso R., Francos-Quijorna I., Olmos-Alonso A., Osta R., Perry V.H., Navarro X., Gomez-Nicola D., López-Vales R.. CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves. Scientific Reports. 13 May 2016. DOI: 10.1038/srep25663.
Impacto: 4.259. Cuartil: Q1
Coll-Miró M., Francos-Quijorna I., Santos-Nogueira E., Torres-Espin A., Bufler P., Dinarello C.A., López-Vales R.. Beneficial effects of IL-37 after spinal cord injury in mice. Proceedings of the National Academy of Sciences of the United States of America. 2 February 2016. DOI: 10.1073/pnas.1523212113.
Impacto: 9.661. Cuartil: Q1
(1er decil)
Ortega-Esteban A., Condezo G.N., Pérez-Berná A.J., Chillón M., Flint S.J., Reguera D., San Martín C., De Pablo P.J.. Mechanics of Viral Chromatin Reveals the Pressurization of Human Adenovirus. ACS Nano. 24 November 2015. DOI: 10.1021/acsnano.5b03417.
Impacto: 13.334. Cuartil: Q1
(1er decil)
Almolda B., González B., Castellano B.. Are microglial cells the regulators of lymphocyte responses in the CNS?. Frontiers in Cellular Neuroscience. 16 November 2015. DOI: 10.3389/fncel.2015.00440.
Impacto: 4.609. Cuartil: Q1
Massó A., Sánchez A., Gimenez-Llort L., Lizcano J.M., Cañete M., Garciá B., Torres-Lista V., Puig M., Bosch A., Chillon M.. Secreted and transmembrane αklotho isoforms have different spatio-temporal profiles in the brain during aging and Alzheimer's disease progression. PLoS ONE. 1 November 2015. DOI: 10.1371/journal.pone.0143623.
Impacto: 3.057. Cuartil: Q1
Peluffo H., Solari-Saquieres P., Negro-Demontel M.L., Francos-Quijorna I., Navarro X., López-Vales R., Sayós J., Lago N.. CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype. Journal of Neuroinflammation. August 12, 2015. DOI: 10.1186/s12974-015-0364-y.
Impacto: 4.667. Cuartil: Q1
Pérez-Yarza E.G., Castro-Rodriguez J.A., Villa Asensi J.R., Garde Garde J., Hidalgo Bermejo F.J., Alćntara M., Aloy G., Antelo C., Asensio O., Bandrés F., Bartolomé M., Cabanes L., Canseco A., Carrasco M., Casanovas J.M., Cortell I., Corcuera P., Corzo J.L., Cobero M., Martin A., De Mir I., Echavarri F., Edo A., Escribano A., Ferrés J., García-Hernández G., Gartner S., Girón F., Herrera L., Korta-Murua J., Larco J.I., López-Silvarey A., Lozano D., Marco N., Martín-Mateos A., Martínez-Cañaavate A.M., Moya M., Navarro M., Oliva C., Pérez-Frías J., Plaza A.M., Rueda S., Salcedo A., Sánchez T., Sardón O., Toral T., Torres J., Valverde-Molina J., Vázquez C., Vela C., Velasco R.. Validation of a Spanish version of the childhood asthma control test (Sc-ACT) for use in Spain. Anales de Pediatria. 1 August 2015. DOI: 10.1016/j.anpedi.2014.10.031.
Impacto: 0.773. Cuartil: Q4
Santos-Nogueira E., López-Serrano C., Hernández J., Lago N., Astudillo A.M., Balsinde J., Estivill-Torrús G., de Fonseca F.R., Chun J., López-Vales R.. Activation of lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury. Journal of Neuroscience. 15 July 2015. DOI: 10.1523/JNEUROSCI.4703-14.2015.
Impacto: 5.924. Cuartil: Q1
Villacampa N., Almolda B., Vilella A., Campbell I.L., González B., Castellano B.. Astrocyte-targeted production of IL-10 induces changes in microglial reactivity and reduces motor neuron death after facial nerve axotomy. GLIA. 1 July 2015. DOI: 10.1002/glia.22807.
Impacto: 5.997. Cuartil: Q1
(1er decil)
Almolda B., de Labra C., Barrera I., Gruart A., Delgado-Garcia J.M., Villacampa N., Vilella A., Hofer M.J., Hidalgo J., Campbell I.L., González B., Castellano B.. Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10. Brain, Behavior, and Immunity. 1 March 2015. DOI: 10.1016/j.bbi.2014.10.015.
Impacto: 5.874. Cuartil: Q1
Thwaite R., Pagès G., Chillón M., Bosch A.. AAVrh.10 immunogenicity in mice and humans. Relevance of antibody cross-reactivity in human gene therapy. Gene Therapy. 7 February 2015. DOI: 10.1038/gt.2014.103.
Impacto: 3.242. Cuartil: Q2
Piedra J., Ontiveros M., Miravet S., Penalva C., Monfar M., Chillon M.. Development of a rapid, robust, and universal PicoGreen-based method to titer adeno-associated vectors. Human Gene Therapy Methods. 1 February 2015. DOI: 10.1089/hgtb.2014.120.
Impacto: 1.986. Cuartil: Q3
Condezo G.N., Marabini R., Ayora S., Carazo J.M., Alba R., Chillón M., Martín C.S.. Structures of adenovirus incomplete particles clarify capsid architecture and show maturation changes of packaging protein L1 52/55k. Journal of Virology. 2015. DOI: 10.1128/JVI.01453-15.
Impacto: 4.606. Cuartil: Q1
Ariza L., Pagès G., García-Lareu B., Cobianchi S., Otaegui P.J., Ruberte J., Chillón M., Navarro X., Bosch A.. Experimental diabetes in neonatal mice induces early peripheral sensorimotor neuropathy. Neuroscience. 22 August 2014. DOI: 10.1016/j.neuroscience.2014.05.015.
Impacto: 3.357. Cuartil: Q2
David M., Machuca-Gayet I., Kikuta J., Ottewell P., Mima F., Leblanc R., Bonnelye E., Ribeiro J., Holen I., Vales R.L., Jurdic P., Chun J., Clézardin P., Ishii M., Peyruchaud O.. Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. Journal of Biological Chemistry. 7 March 2014. DOI: 10.1074/jbc.M113.533232.
Impacto: 4.573. Cuartil: Q1
Ariza L., Giménez-Llort L., Cubizolle A., Pagès G., García-Lareu B., Serratrice N., Cots D., Thwaite R., Chillón M., Kremer E.J., Bosch A.. Central nervous system delivery of helper-dependent canine adenovirus corrects neuropathology and behavior in mucopolysaccharidosis type VII mice. Human Gene Therapy. 1 March 2014. DOI: 10.1089/hum.2013.152.
Impacto: 3.755. Cuartil: Q1
Homs J., Pagès G., Ariza L., Casas C., Chillón M., Navarro X., Bosch A.. Intrathecal administration of IGF-I by AAVrh10 improves sensory and motor deficits in a mouse model of diabetic neuropathy. Molecular Therapy Methods and Clinical Development. 8 January 2014. DOI: 10.1038/mtm.2013.7.
Almolda B., Villacampa N., Manders P., Hidalgo J., Campbell I.L., González B., Castellano B.. Effects of astrocyte-targeted production of interleukin-6 in the mouse on the host response to nerve injury. GLIA. July 2014. DOI: 10.1002/glia.22668.
Impacto: 6.031. Cuartil: Q1
Miralles M., Garcia M., Tejero M., Bosch A., Chillón M.. Production of chimeric adenovirus. Methods in Molecular Biology. 2014. DOI: 10.1007/978-1-62703-679-5_16.
David S., Lòpez-Vales R.. Expression and role of phospholipase A<inf>2</inf> in central nervous system injury and disease. Phospholipases in Health and Disease. 1 January 2014. DOI: 10.1007/978-1-4939-0464-8_9.
Chillón M., Bosch A.. Preface. Methods in Molecular Biology. 2014. DOI: 10.1007/978-1-62703-679_5.
Miravet S., Ontiveros M., Piedra J., Penalva C., Monfar M., Chillón M.. Construction, production, and purification of recombinant adenovirus vectors. Methods in Molecular Biology. 2014. DOI: 10.1007/978-1-62703-679-5_12.
Ariza L., Zaguirre M., García M., Blasco E., Rabanal R.M., Bosch A., Otaegui P.J.. Hyperglycemia and hepatic tumors in ICR mice neonatally injected with streptozotocin. Lab Animal. July 2014. DOI: 10.1038/laban.530.
Impacto: 0.742. Cuartil: Q3